REVERSAL Trial
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REVERSAL Trial On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Objective
To compare the effects of pravastatin and atorvastatin on coronary artery plaque burden and progression by intensive lipid lowering.
Methods
Reversal of Atherosclerosis with Aggressive Lipid Lowering [REVERSAL] was a multicentered, randomized, double- blinded trial wherein 654 patients received the study drug. IVUS examinations were performed at baseline and after 18 months of treatment in 502 patients. Patients randomly received either 40 mg pravastatin or 80 mg of atorvastatin.
Results
The mean LDL-C levels reduced from 150 to 110 mg/dL in the pravastatin group and to 79 mg/dL in the atorvastatin. Percentage change in atheroma volume showed a significantly lower progression rate in the atorvastatin (intensive) group compared to the pravastatin group.
Conclusion
In patients with coronary artery disease, atorvastatin reduced progression of coronary atherosclerosis compared with pravastatin.[1]