High density lipoprotein epidemiology and demographics
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aarti Narayan, M.B.B.S [2]; Raviteja Guddeti, M.B.B.S. [3]
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Overview
Epidemiological studies have shown that high concentrations of HDL (over 60 mg/dL) have protective value against cardiovascular diseases such as ischemic stroke and myocardial infarction. Low concentrations of HDL (below 40 mg/dL for men, below 50 mg/dL for women) are a positive risk factor for these atherosclerotic diseases.
Data from the landmark Framingham Heart Study showed that for a given level of LDL, the risk of heart disease increases 10-fold as the HDL varies from high to low. Conversely, for a fixed level of HDL, the risk increases 3-fold as LDL varies from low to high.
Epidemiology and Demographics
Epidemiological data showed the significant association of low HDL level, as an independent factor with the development of CHD. For each 1% decrease in HDL level, there is an increase in the risk of CHD development by 2-3%.[1]
A large epidemiological study has been set out to determine the prevalence of low HDL 11 European countries. The study population includ 8545 patients receiving treatment for dyslipidaemia, This treatment appeared to exert little or no effect on the prevalence of low HDL-cholesterol, which was slightly higher than that measured in the overall population. Low HDL-cholesterol was present in 33% of men and 40% of women, with very low HDL-cholesterol present in 14% (both genders combined). The prevalence was found much higher in diabetic patients compared to general population. [2]
References
- ↑ National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) (2002). "Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report". Circulation. 106 (25): 3143–421. PMID 12485966.
- ↑ "Epidemiology of low HDL-cholesterol: results of studies and surveys". Retrieved 20 September 2013.