APOA2

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Apolipoprotein A-II
PDB rendering based on 1l6l.
Available structures
PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB
Identifiers
Symbols APOA2 ;
External IDs Template:OMIM5 Template:MGI HomoloGene: 1242
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Apolipoprotein A-II, also known as APOA2, is a human gene.

This gene encodes apolipoprotein (apo-) A-II, which is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia.[1] ApoA2 might play a role in imparing the metabolism of VLDL and promoting the formation of visceral fat.[2]

References

  1. ↑ "Entrez Gene: APOA2 apolipoprotein A-II".
  2. ↑ van 't Hooft FM, Ruotolo G, Boquist S, de Faire U, Eggertsen G, Hamsten A (2001). "Human evidence that the apolipoprotein a-II gene is implicated in visceral fat accumulation and metabolism of triglyceride-rich lipoproteins". Circulation. 104 (11): 1223–8. PMID 11551871.

Further reading

  • Blanco-Vaca F, Escolà-Gil JC, Martín-Campos JM, Julve J (2002). "Role of apoA-II in lipid metabolism and atherosclerosis: advances in the study of an enigmatic protein". J. Lipid Res. 42 (11): 1727–39. PMID 11714842.
  • Kalopissis AD, Pastier D, Chambaz J (2003). "Apolipoprotein A-II: beyond genetic associations with lipid disorders and insulin resistance". Curr. Opin. Lipidol. 14 (2): 165–72. doi:10.1097/01.mol.0000064047.08840.50. PMID 12642785.
  • Vollmer E, Brust J, Roessner A; et al. (1991). "Distribution patterns of apolipoproteins A1, A2, and B in the wall of atherosclerotic vessels". Virchows Archiv. A, Pathological anatomy and histopathology. 419 (2): 79–88. PMID 1908160.
  • Deeb SS, Takata K, Peng RL; et al. (1990). "A splice-junction mutation responsible for familial apolipoprotein A-II deficiency". Am. J. Hum. Genet. 46 (4): 822–7. PMID 2107739.
  • Gordon JI, Sims HF, Edelstein C; et al. (1985). "Extracellular processing of proapolipoprotein A-II in Hep G2 cell cultures is mediated by a 54-kDa protease immunologically related to cathepsin B.". J. Biol. Chem. 260 (27): 14824–31. PMID 2414299.
  • Tsao YK, Wei CF, Robberson DL; et al. (1986). "Isolation and characterization of the human apolipoprotein A-II gene. Electron microscopic analysis of RNA:DNA hybrids, nucleotide sequence, identification of a polymorphic MspI site, and general structural organization of apolipoprotein genes". J. Biol. Chem. 260 (28): 15222–31. PMID 2415515.
  • Lackner KJ, Law SW, Brewer HB (1985). "The human apolipoprotein A-II gene: complete nucleic acid sequence and genomic organization". Nucleic Acids Res. 13 (12): 4597–608. PMID 2989800.
  • Knott TJ, Wallis SC, Robertson ME; et al. (1985). "The human apolipoprotein AII gene: structural organization and sites of expression". Nucleic Acids Res. 13 (17): 6387–98. PMID 2995928.
  • Chan L, Moore MN, Tsao YK (1986). "Molecular cloning and sequence analysis of human apolipoprotein A-II cDNA". Meth. Enzymol. 128: 745–52. PMID 3088392.
  • Middleton-Price HR, van den Berghe JA, Scott J; et al. (1988). "Regional chromosomal localisation of APOA2 to 1q21-1q23". Hum. Genet. 79 (3): 283–5. PMID 3136074.
  • Shelley CS, Sharpe CR, Baralle FE, Shoulders CC (1986). "Comparison of the human apolipoprotein genes. Apo AII presents a unique functional intron-exon junction". J. Mol. Biol. 186 (1): 43–51. PMID 3935800.
  • Brewer HB, Lux SE, Ronan R, John KM (1972). "Amino acid sequence of human apoLp-Gln-II (apoA-II), an apolipoprotein isolated from the high-density lipoprotein complex". Proc. Natl. Acad. Sci. U.S.A. 69 (5): 1304–8. PMID 4338591.
  • Lux SE, John KM, Ronan R, Brewer HB (1973). "Isolation and characterization of the tryptic and cyanogen bromide peptides of apoLp-Gln-II (apoA-II), plasma high density apolipoprotein". J. Biol. Chem. 247 (23): 7519–27. PMID 4344225.
  • Moore MN, Kao FT, Tsao YK, Chan L (1984). "Human apolipoprotein A-II: nucleotide sequence of a cloned cDNA, and localization of its structural gene on human chromosome 1". Biochem. Biophys. Res. Commun. 123 (1): 1–7. PMID 6089788.
  • Lackner KJ, Law SW, Brewer HB (1984). "Human apolipoprotein A-II: complete nucleic acid sequence of preproapo A-II". FEBS Lett. 175 (1): 159–64. PMID 6090207.
  • Gordon JI, Budelier KA, Sims HF; et al. (1984). "Biosynthesis of human preproapolipoprotein A-II". J. Biol. Chem. 258 (22): 14054–9. PMID 6315718.
  • Sharpe CR, Sidoli A, Shelley CS; et al. (1984). "Human apolipoproteins AI, AII, CII and CIII. cDNA sequences and mRNA abundance". Nucleic Acids Res. 12 (9): 3917–32. PMID 6328445.
  • Stoffel W, Krüger E, Deutzmann R (1983). "Cell-free translation of human liver apolipoprotein AI and AII mRNA. Processing of primary translation products". Hoppe-Seyler's Z. Physiol. Chem. 364 (3): 227–37. PMID 6407957.
  • Knott TJ, Priestley LM, Urdea M, Scott J (1984). "Isolation and characterisation of a cDNA encoding the precursor for human apolipoprotein AII". Biochem. Biophys. Res. Commun. 120 (3): 734–40. PMID 6428397.
  • Lackner KJ, Law SW, Brewer HB; et al. (1984). "The human apolipoprotein A-II gene is located on chromosome 1". Biochem. Biophys. Res. Commun. 122 (3): 877–83. PMID 6433912.

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