WBR279
| Author | PageAuthor::Gerald Chi |
|---|---|
| Exam Type | ExamType::USMLE Step 1 |
| Main Category | MainCategory::Microbiology, MainCategory::Pharmacology |
| Sub Category | SubCategory::Dermatology |
| Prompt | [[Prompt::A 15-year-old girl comes to the clinic after being bitten by a neighbor's dog. On examination, she has a 5 inch-long wound on her calf.There are also teeth marks suggestive of deep punctures. Two days later, she begins to have mild fever and the wound on her leg becomes swollen and erythematous. If antibiotic therapy is indicated, which of the following drugs should be used in this case?]] |
| Answer A | AnswerA::Amoxicillin-Clavulanate |
| Answer A Explanation | [[AnswerAExp::Correct - This bacterium is somewhat unusual in that it can be effectively treated with beta-lactam antibiotics, despite its Gram-negative structure. It is also often treated with fluoroquinolones or tetracyclines; fluoroquinolones inhibit bacterial DNA synthesis and tetracyclines interfere with protein synthesis by binding to the bacterial 30S ribosomal subunit.]] |
| Answer B | AnswerB::Cephalexin |
| Answer B Explanation | AnswerBExp::Incorrect - P. multocida is reported to be resistant to dicloxacillin, cephalexin, and clindamycin; many strains are resistant to erythromycin. |
| Answer C | AnswerC::Clindamycin |
| Answer C Explanation | AnswerCExp::Incorrect - P. multocida is reported to be resistant to dicloxacillin, cephalexin, and clindamycin; many strains are resistant to erythromycin. |
| Answer D | AnswerD::Dicloxacillin |
| Answer D Explanation | AnswerDExp::Incorrect - P. multocida is reported to be resistant to dicloxacillin, cephalexin, and clindamycin; many strains are resistant to erythromycin. |
| Answer E | AnswerE::Erythromycin |
| Answer E Explanation | AnswerEExp::Incorrect - P. multocida is reported to be resistant to dicloxacillin, cephalexin, and clindamycin; many strains are resistant to erythromycin. |
| Right Answer | RightAnswer::A |
| Explanation | [[Explanation::Pasteurella multocida is a small, Gram-negative, non-motile coccobacillus that is penicillin-sensitive. It can cause a zoonotic infection in humans, which typically is a result of bites or scratches from pets (such as cats and dogs). Many mammals and fowl harbor it as part of their normal respiratory microbiota, displaying asyptomatic infections. Educational Objective: |
| Approved | Approved::No |
| Keyword | WBRKeyword::Pasteurella multocida |
| Linked Question | Linked:: |
| Order in Linked Questions | LinkedOrder:: |