Low density lipoprotein future or investigational therapies
Low Density Lipoprotein Microchapters |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief:
Overview
The Unmet Need Driving Research Into Lowering LDL
Investigational Therapies
Inhibition of Apolipoprotein B production
PCSK9 Inhibition
Monoclonal Antibodies
Antisense Oligonucleotides (ASO)
Small Interfering RNAs (SiRNAs)
Microsomal Triglyceride Transfer Protein (MTP) Inhibition
Thyromimetics
Squalene Synthase Inhibition
Table
Class | Drug Company | Agent Name | Mechanism of Action | Efficacy on Lowering LDL-C | Route of Administration | Adverse Effects | Published Clinical Trials |
---|---|---|---|---|---|---|---|
Inhibition of Apo B | |||||||
PCSK9 Inhibition | |||||||
MTP Inhibition | |||||||
Thyromimetics | |||||||
Squalene Synthase Inhibitors | |||||||
References