IgA nephropathy causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Overview
Causes
Primary IgA Nephropathy
Primary IgA nephropathy is caused by a genetic predisposition in patients who typically present immediately following a respiratory or gastrointestinal tract infectious organisms or virus. The environmental exposure to these infectious agents may thus facilitate the subsequent pathogenesis of the disease.
Secondary IgA Nephropathy
Common primary etiologies associated with glomerular IgA deposits and thus secondary IgA nephropathy are shown below.
The most important 3 causes are:
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IgA nephropathy has also been associated with the following diseases, but to a much less extent:
- Dermatitis herpetiformis[1]
- Seronegative arthritis, especially as ankylosing spondylitis[1]
- Small-cell carcinoma[1]
- Hodgkin’s lymphoma[1]
- T-cell lymphoma, such as mycosis fungoides[1]
- Disseminated tuberculosis[1]
- Bronchiolitis obliterans[1]
- Inflammatory bowel disease (Crohn’s disease and ulcerative colitis)[1]