WBR0633
| Author | [[PageAuthor::Rim Halaby, M.D. [1]]] |
|---|---|
| Exam Type | ExamType::USMLE Step 1 |
| Main Category | MainCategory::Microbiology, MainCategory::Pharmacology |
| Sub Category | SubCategory::Infectious Disease |
| Prompt | [[Prompt::A 24 year old woman is referred to an infectious disease specialist for 3 weeks of fatigue, sore throat, and generalized lymphadenopathy. The patient is diagnosed with a protozoal illness and the physician decides to initiate therapy. He explains to the patient that the drug he intends to use works by a similar mechanism to a chemotherapeutic agent that causes bone marrow suppression. He reassures the patient that much like the chemotherapeutic agent, if this medication were to affect her, addition of folinic acid to her treatment would correct the bone marrow effects. Which of the following drugs is the physician prescribing to this patient?]] |
| Answer A | AnswerA::Sodium Stibogluconate |
| Answer A Explanation | AnswerAExp:: |
| Answer B | AnswerB::Suramin/Melarsoprol |
| Answer B Explanation | AnswerBExp:: |
| Answer C | AnswerC::Nifurtimox |
| Answer C Explanation | AnswerCExp:: |
| Answer D | AnswerD::Pyrimethamine |
| Answer D Explanation | AnswerDExp:: |
| Answer E | AnswerE::TMP/SMX |
| Answer E Explanation | AnswerEExp:: |
| Right Answer | RightAnswer:: |
| Explanation | [[Explanation::Pyrimethamine is an antiprotozoal agent that acts by a similar mechanism to methotrexate and trimethoprim by inhibiting the enzyme dihydrofolate reductase (DHFR) thus leading to the inhibition of thymidine synthesis and DNA secondarily. The commmon side effect of this class of medications is the interaction with human Educational Objective: |
| Approved | Approved::No |
| Keyword | |
| Linked Question | Linked:: |
| Order in Linked Questions | LinkedOrder:: |