WBR0641
| Author | [[PageAuthor::Rim Halaby, M.D. [1]]] |
|---|---|
| Exam Type | ExamType::USMLE Step 1 |
| Main Category | MainCategory::Immunology |
| Sub Category | SubCategory::Hematology |
| Prompt | [[Prompt::A 7 month old boy is brought the emergency room for bloody diarrhea. The mother explains that she had been noticing blood tinged stools for the past week but today, she noted frank blood in the diapers. On admission, the child appears well, his pulse is 123 and his temperature is 36.8C. Physical exam reveals multiple petechiae in the oral cavity. Skin shows purpura most prominent on the legs and patchy eczema affecting the limbs, face, and trunk. Upon further questioning, the mother reports that the child has a history of multiple hospital admissions for recurrent respiratory tract infections. Which of the following describes the pathophysiology of the disease most likely present in this child?]] |
| Answer A | AnswerA::Defect in DNA repair enzymes |
| Answer A Explanation | AnswerAExp:: |
| Answer B | AnswerB::T-cell inability to reorganize cytoskeleton |
| Answer B Explanation | AnswerBExp:: |
| Answer C | AnswerC::Defect in lysosomal trafficking |
| Answer C Explanation | AnswerCExp:: |
| Answer D | AnswerD::Defect in Th1 response |
| Answer D Explanation | AnswerDExp:: |
| Answer E | AnswerE::Defect in CD18 protein on phagocytes |
| Answer E Explanation | AnswerEExp:: |
| Right Answer | RightAnswer::B |
| Explanation | [[Explanation:: Educational Objective: |
| Approved | Approved::No |
| Keyword | |
| Linked Question | Linked:: |
| Order in Linked Questions | LinkedOrder:: |