WBR0170
| Author | [[PageAuthor::Rim Halaby, M.D. [1]]] |
|---|---|
| Exam Type | ExamType::USMLE Step 1 |
| Main Category | MainCategory::Pathophysiology |
| Sub Category | SubCategory::Genitourinary |
| Prompt | [[Prompt::A 38 year old woman presents to the physician's office complaining of fatigue, hot flashes, and facial flushing. Upon further questioning, she also informs the physician that she has not had her menses for 14 months. Following appropriate work-up, the diagnosis of premature ovarian failure (POF) is made. Which of the following set of lab results are most likely seen in this patient?
|
| Answer A | AnswerA::A |
| Answer A Explanation | AnswerAExp::This is not the correct set of lab results. |
| Answer B | AnswerB::B |
| Answer B Explanation | AnswerBExp::This is the correct set of lab results. |
| Answer C | AnswerC::C |
| Answer C Explanation | AnswerCExp::This is not the correct set of lab results. |
| Answer D | AnswerD::D |
| Answer D Explanation | AnswerDExp::This is not the correct set of lab results. |
| Answer E | AnswerE::E |
| Answer E Explanation | AnswerEExp::This is not the correct set of lab results. |
| Right Answer | RightAnswer::B |
| Explanation | [[Explanation::The patient is presenting with premature ovarian failure (POF), a state of primary ovarian defect characterized by depletion of ovarian follicle reserve before 40 years of age. Patients with POF might have primary amenorrhea, where menarche has been absent since birth, or secondary amenorrhea, where patients stopped having menses before 40 years. The clinical signs and symptoms of POF are similar to menopause. Patients typically present with hot flashes, fatigue, and facial flushing. Lab work-up also reveals a marked decrease in ovarian hormones, estrogen and progesterone, and a significant increase in pituitary hormones, LH and FSH, that are no longer regulated by feedback inhibition.
Educational Objective: Premature ovarian failure (POF) is a state of primary ovarian defect which mimics menopause before the age of 40. Ovarian hormones are decreased, while pituitary hormones are increased due to absence of feedback inhibition. Reference:
Beck-Peccoz P, Persani L. Premature ovarian failure. Orphanet J Rare Dis. 2006; 1:9. |
| Approved | Approved::No |
| Keyword | WBRKeyword::premature, WBRKeyword::ovarian, WBRKeyword::failure, WBRKeyword::menopause, WBRKeyword::postmenopause, WBRKeyword::post, WBRKeyword::post-menopause, WBRKeyword::LH, WBRKeyword::FSH, WBRKeyword::progesterone, WBRKeyword::hormone, WBRKeyword::hormonal, WBRKeyword::changes, WBRKeyword::change, WBRKeyword::fatigue, WBRKeyword::facial, WBRKeyword::flushing, WBRKeyword::flush, WBRKeyword::flushes, WBRKeyword::flash, WBRKeyword::flashes, WBRKeyword::heat, WBRKeyword::hot |
| Linked Question | Linked:: |
| Order in Linked Questions | LinkedOrder:: |
