Iodoquinol
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
The quinoline derivative diiodohydroxyquinoline (INN) or iodoquinol (USAN) can be used in the treatment of amoebiasis.[1] It is poorly absorbed from the gastrointestinal tract and is used as a luminal amebicide. It was discovered by Adco Co. and introduced as diiodohydroxyquinoline.[2] Susceptibility of Dientamoeba fragilis has been measured.[3]
Category
Amebicide
US Brand Names
ALA-SEPTIC®, ALCORTIN®, ALCORTIN A®, ALOQUIN®, DERMAZENE®, HYDROCORTISONE IODOQUINOL cream®, VYTONE cream®
FDA Package Insert
Description | Clinical Pharmacology | Microbiology | Indications and Usage | Contraindications | Warnings and Precautions | Adverse Reactions | Dosage and Administration | How Supplied | Labels and Packages
Mechanisms of Action
Iodoquinol acts by chelation of Fe2+ which is essential for metabolism.[4]
References
- ↑ Ghaskadbi S, Vaidya VG (1989). "In vivo antimutagenic effect of ascorbic acid against mutagenicity of the common antiamebic drug diiodohydroxyquinoline". Mutat. Res. 222 (3): 219–22. doi:10.1016/0165-1218(89)90137-7. PMID 2493578. Unknown parameter
|month=ignored (help) - ↑ Page 1312. http://books.google.co.in/books?id=TIu28TH_iAYC&printsec=frontcover&source=gbs_ge_summary_r&cad=0#v=onepage&q&f=false
- ↑ Chan FT, Guan MX, Mackenzie AM, Diaz-Mitoma F (1994). "Susceptibility testing of Dientamoeba fragilis ATCC 30948 with iodoquinol, paromomycin, tetracycline, and metronidazole". Antimicrob. Agents Chemother. 38 (5): 1157–60. PMC 188168. PMID 8067755. Unknown parameter
|month=ignored (help) - ↑ Gideon Online http://web.gideononline.com/web/therapy/index.php?type=drugs&code=20130&view=General. Missing or empty
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