Cefpirome

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Cefpirome is a fourth-generation cephalosporin which is considered highly active against Gram-positive bacteria and Gram-negative bacteria including Pseudomonas aeruginosa. It is marketed under the brand name of CEFROM by Sanofi Aventis group India.

Category

Cephalosporin, Fourth-Generation

Mechanism of Action

Cefpirome blocks bacterial cell wall synthesis by binding to penicillin binding proteins. Cefpirome (not available in the United States) and cefepime are fourth-generation cephalosporins which possess antibacterial activity against several fastidious Gram negative bacteria.

Spectrum of Bacterial Susceptibility and Resistance

Currently, Bacteroides fragilis, Enterococci, Pseudomonas spp. and Staphylococci are resistant to Cefpirome Sulfate, and some Haemophilus spp. and Pneumococci have developed resistance to Cefpirome Sulfate to varying degrees.