Cefamandole nafate

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Cefamandole (INN, also known as cephamandole) is a second-generation broad-spectrum cephalosporin antibiotic. The clinically used form of cefamandole is the formate ester cefamandole nafate, a prodrug which is administered parenterally.

Cefamandole is no longer available in the United States.

Adverse effects

The chemical structure of cefamandole, like that of several other cephalosporins, contains an N-methylthiotetrazole (NMTT or 1-MTT) side chain. As the antibiotic is broken down in the body, it releases free NMTT, which can cause hypoprothrombinemia (likely due to inhibition of the enzyme vitamin K epoxide reductase)(vitamin K supplement is recommended during therapy) and a reaction with ethanol similar to that produced by disulfiram (Antabuse), due to inhibition of aldehyde dehydrogenase.

Spectrum of Bacterial Susceptibility

Cefamandole has a broad spectrum of activity and can be used to treat bacterial infections of the skin, bones and joints, urinary tract, and lower respiratory tract. The following represents cefamandole MIC susceptibility data for a few medically significant microorganisms.

Escherichia coli: 0.12 μg/mL - 400 μg/mL
Haemophilus influenzae: 0.06 μg/mL - >16 μg/mL
Staphylococcus aureus: 0.1 μg/mL - 12.5 μg/mL

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Report

CO2 is generated during the normal constitution of cefamandole & ceftazidim resulting in explosive like reaction in syringe

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US Brand Names

FDA Package Insert

Mechanism of Action

References

↑ http://www.toku-e.com/Assets/MIC/Cefamandole%20sodium%20salt.pdf
↑ Stork CM (2006). "Antibiotics, antifungals, and antivirals". In Nelson LH, Flomenbaum N, Goldfrank LR, Hoffman RL, Howland MD, Lewin NA (eds.). Goldfrank's toxicologic emergencies. New York: McGraw-Hill. p. 847. ISBN 0-07-143763-0. Retrieved 2009-07-03.

[1] ttp://www.toku-e.com/Assets/MIC/Cefamandole%20sodium%20salt.pdf

[Goldfrank-2] Stork CM (2006). "Antibiotics, antifungals, and antivirals". In Nelson LH, Flomenbaum N, Goldfrank LR, Hoffman RL, Howland MD, Lewin NA (eds.). Goldfrank's toxicologic emergencies. New York: McGraw-Hill. p. 847. ISBN 0-07-143763-0. Retrieved 2009-07-03.

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