Norfloxacin
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Norfloxacin is a synthetic chemotherapeutic antibacterial agent[1][2] occasionally used to treat common as well as complicated urinary tract infections.[3] It is sold under various brand names with the most common being Noroxin. In form of ophthalmic solutions it is known as Chibroxin (Apiflox eye drops in Jordan [4]). Norfloxacin is a first generation synthetic fluoroquinolone (quinolone) developed by Kyorin Seiyaku K.K. (Kyorin).[5]
Category
Fluoroquinolone
US Brand Names
NOROXIN®,CHIBROXIN®
FDA Package Insert
Description | Clinical Pharmacology | Microbiology | Indications and Usage | Contraindications | Warnings and Precautions | Adverse Reactions | Drug Interactions | Overdosage | Clinical Studies | Dosage and Administration | How Supplied | Labels and Packages
Mechanism of Action
Norfloxacin inhibits bacterial deoxyribonucleic acid synthesis and is bactericidal. At the molecular level, three specific events are attributed to norfloxacin in E. coli cells:
inhibition of the ATP-dependent DNA supercoiling reaction catalyzed by DNA gyrase, inhibition of the relaxation of supercoiled DNA, promotion of double-stranded DNA breakage.
References
- ↑ Nelson, JM.; Chiller, TM.; Powers, JH.; Angulo, FJ. (2007). "Fluoroquinolone-resistant Campylobacter species and the withdrawal of fluoroquinolones from use in poultry: a public health success story". Clin Infect Dis. 44 (7): 977–80. doi:10.1086/512369. PMID 17342653. Unknown parameter
|month=ignored (help) - ↑ Padeĭskaia, EN. (2003). "[Norfloxacin: more than 20 years of clinical use, the results and place among fluoroquinolones in modern chemotherapy for infections]". Antibiot Khimioter. 48 (9): 28–36. PMID 15002177.
- ↑ Rafalsky, V.; Andreeva, I.; Rjabkova, E.; Rafalsky, Vladimir V (2006). Rafalsky, Vladimir V, ed. "Quinolones for uncomplicated acute cystitis in women". Cochrane Database Syst Rev. 3: CD003597. doi:10.1002/14651858.CD003597.pub2. PMID 16856014.
- ↑ http://www.jfda.jo/
- ↑ "HQ 545710". faqs.org. 30 October 1998.