Sandbox vidit3

Drug	Clinical course	Stable
Physical examination	No evidence of heart failure
Functional class	I/II
6MWD	Greater than 400 m
Echocardiogram	RV size normal
Hemodynamics	RAP normal CI normal
BNP	Near normal or stable
Treatment	Oral therapy
Frequency of evaluation	Q 3 to Q 6 months
FC assessment	Every clinic visit
6MWT	Every clinic visit
Echocardiogram2	Q 12 months/center dependent
BNP	center dependent
RHC	Clinical deterioration and center dependent

Drug	Clinical course	Unstable
Physical examination	Signs of heart failure
Functional class	IV
6MWD	Less than 400 m
Echocardiogram	RV Enlargement
Hemodynamics	RAP high CI low
BNP	Elevated/Increasing
Treatment	Intravenous prostacyclin and/or combination treatment
Frequency of evaluation	Q 1 to Q 3 months
FC assessment	Every clinic visit
6MWT	Every clinic visit
Echocardiogram2	Q 6 to Q 12 months/center dependent
BNP	center dependent
RHC	Q 6 to Q 12 months or clinical deterioration