Renal cell carcinoma epidemiology and demographics
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Overview
Renal cell carcinoma is considered the 7th most common cancer in men and 9th most common cancer in women, accounting for approximately 2-3% of malignant tumors in adults. Men are twice more likely to be affected than women with an mean age of presentation at 60 years. Most renal cell carcinomas develop sporadically, while only a small number of cases are of genetic diseases. Clear cell carcinomas are the most common renal cell carcinomas and collecting-duct carcinomas are the least common. Renal cell carcinomas are mostly found incidentally during radiological abdominal work-up.
Epidemiology
Renal cell carcinomas is considered the 7th most common cancer in men and the 9th most common cancer in women. It account for approximately 2-3% of all malignant tumors in the adult population.[1] More than 70% of renal cell carcinomas are clear cell carcinomas. Papillary carcinomas are the second most common renal cell carcinomas. The least common types of renal cell carcinomas are collecting-duct renal cell carcinomas, accounting for less than 1% of all cases.[2] Most cases of renal cell carcinoma are sporadic; whereas only approximately 2-3% of all cases are familial, most of which have an autosomal-dominant pattern of inheritance.[1]
The male to female ratio is approximately 2 to 1.[1] The ratio increases dramatically increases in sporadic cases of papillary renal cell carcinomas, reaching a 5 to 1 ratio.[2] The median age of presentation is typically 60 years. Presentation might range from a much more common asymptomatic course (incidental finding) to a less likely local or paraneoplastic/systemic presentation.[1]
References
- ↑ 1.0 1.1 1.2 1.3 Rini BI, Campbell SC, Escudier B (2009). "Renal cell carcinoma". Lancet. 373 (9669): 1119–32. doi:10.1016/S0140-6736(09)60229-4. PMID 19269025.
- ↑ 2.0 2.1 Cohen HT, McGovern FJ (2005). "Renal-cell carcinoma". N Engl J Med. 353 (23): 2477–90. doi:10.1056/NEJMra043172. PMID 16339096.