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H. Influenzae Preferred Regimen ▸ Ceftriaxone 50 mg/kg IV q12h If Penicillin Allergic ▸ Chloramphenicol 12.5 mg/kg IV q6h (max. 4 gm/day.) Listeria Monocytogenes Preferred Regimen ▸ Ampicillin 50 mg/kg IV q12h 2mg iv q4h PLUS OR NOT ▸ gentamicin 2 mg/kg loading dose then 1.7kg/mg q8h If Penicillin Allergic ▸ TMP-SMX 20 mg/kg/day q6–12h Alternative Regimen ▸ Meropenem 2 mg IV q8h N. meningitidis Preferred Regimen ▸Ceftriaxone 2 mg IV q12hx 7 days ▸If Ȕ-Lactam Allergic ▸Chloro 12.5 mg/kg (up to 1 gm) IV q6h Alternative Regimen ▸Meropenem 2 gm IV q8h OR Moxifloxacin 400 mg q24h

S. pneumoniae‡ Pen G MIC <0.1 mcg/mL ▸ Pen G 4 million units IV q4h OR AMP 2 gm IV q4h Alternative Regimen ▸Ceftriaxone 2 gm IV q12h OR Chloro 1 gm IV q6h Pen G MIC :0.1–1 mcg/mL ▸Ceftriaxone 2 gm IV q12h OR Cefotaxime 2 gm IV q4–6h Alternative Regimen ▸Cefepime 2 gm IV q8h OR MER 2 gm IV q8h Pen G MIC :≥2 mcg/mL ▸ Vanco 500–750 mg IV q6h PLUS ▸ceftriaxone 2 gm IV q12h OR Cefotaxime 2 gm IV q4–6h Alternative Regimen ▸Moxi 400 mg IV q24h Ceftriaxone MIC ≥ 1mcg/mL ▸ Vanco 500–750 mg IV q6h PLUS ▸ceftriaxone 2 gm IV q12h OR Cefotaxime 2 gm IV q4–6h Alternative Regimen