Abciximab contraindications
Template:Abciximab Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sheng Shi, M.D. [2], Pratik Bahekar, MBBS [3]
Contraindications
Because Abciximab may increase the risk of bleeding, Abciximab is contraindicated in the following clinical situations:
- Active internal bleeding
- Recent (within six weeks) gastrointestinal (GI) or genitourinary (GU) bleeding of clinical significance.
- History of cerebrovascular accident (CVA) within two years, or CVA with a significant residual neurological deficit
- Bleeding diathesis
- Administration of oral anticoagulants within seven days unless prothrombin time is <1.2 times control
- Thrombocytopenia (<100 000 cells/m L)
- Recent (within six weeks) major surgery or trauma
- Intracranial neoplasm, arteriovenous malformation, or aneurysm
- Severe uncontrolled hypertension
- Presumed or documented history of vasculitis
- Use of intravenous dextran before PCI, or intent to use it during an intervention
- Abciximab is also contraindicated in patients with known hypersensitivity to any component of this product or to murine proteins.[1]
References
Adapted from the FDA Package Insert.