Bivalirudin

Brand Names / Synonyms: Angiomax, Angiox

Dosing and Administration

PCI/PCTA Adults

IV Bolus dose of 0.75 mg/kg followed by an infusion of 1.75 mg/kg/h for duration of PCI procedure. Five minutes after bolus dose, obtain ACT and administer additional bolus of 0.3 mg/kg if indicated.

HIT/HITTS Adults

IV Bolus dose of 0.75 mg/kg, followed by a continuous infusion at a rate of 1.75 mg/kg/h for the duration of the procedure.

Continuation of Therapy Adults

IV Infusion may be continued for up to 4 h post-procedure as indicated. After 4 h, an additional IV infusion of 0.2 mg/kg/h for up to 20 h may be given if needed.

Concomitant Therapy Adults

Bivalirudin is intended for concurrent use with aspirin (300 to 325 mg/day).

Renal Function Impairment Adults

IV Ccr 30 to 50 mL/min: Administer infusion at rate of 1.75 mg/kg/h. Ccr less than 30 mL/min: Reduce infusion rate to 1 mg/kg/h. Hemodialysis: Reduce infusion rate to 0.25 mg/kg/h. No reduction in bolus dose needed.

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