Acute tubular necrosis causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [2]

Causes

Ischemic Acute Tubular Necrosis

Renal hypoperfusion is the major cause of ischemic ATN. A decrease in blood pressure to the extent that renal protective mechanisms fail to maintain adequate perfusion leads to ATP depletion and cell necrosis. Some etiologies associated with ischemic ATN include:

• Hypotension
• Sepsis
• Cardiogenic shock
• Renal vein thrombosis
• ACE inhibitors
• Angiotensin receptor blockers
• NSAIDs

References

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