Topiramate use in specific populations

Topiramate
TOPIRAMATE® FDA Package Insert
Indications and Usage
Dosage and Administration
Dosage Forms and Strengths
Contraindications
Warnings and Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Overdosage
Description
Clinical Pharmacology
Nonclinical Toxicology
Clinical Studies
How Supplied/Storage and Handling
Patient Counseling Information
Labels and Packages
Clinical Trials on Topiramate
ClinicalTrials.gov

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Pratik Bahekar, MBBS [2]

For patient information, click here.

Specific Populations

• Renal impairment: In renally impaired patients (creatinine clearance less than 70 mL/min/1.73 m2), one-half of the adult dose is recommended.
• Patients undergoing hemodialysis: Topiramate is cleared by hemodialysis. Dosage adjustment is necessary to avoid rapid drops in topiramate plasma concentration during hemodialysis.
• Pregnancy: Increased risk of cleft lip and/or palate. Pregnancy registry available.
• Nursing mothers: Caution should be exercised when administered to a nursing mother .
• Geriatric use: Dosage adjustment may be necessary for elderly with impaired renal function.