Sandbox Abciximab

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Sandbox Abciximab
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sheng Shi, M.D. [2]

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Overview

Sandbox Abciximab is a Platelet aggregation inhibitor that is FDA approved for the {{{indicationType}}} of prevention of cardiac ischemic complications in patients undergoing percutaneous coronary intervention and in patients with unstable angina not responding to conventional medical therapy when percutaneous coronary intervention is planned within 24 hours. Common adverse reactions include Chest pain , Hypotension ,Injection site pain ,Abdominal pain , Nausea, Vomiting Bleeding Backache.

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

Preparation of PCI
  • Dosing Information
  • initial dosage:0.25 mg/kg IV bolus (10-60 minutes before the start of PCI)
  • maitaining dosage: 0.125 mg/kg/min IV for 12 hours (max 10 ug/min)
Treatment of patient with unstable angina planned to undergo PCI within 24 hours
  • Dosing Information
  • initial dosage:0.25 mg/kg IV (10-60 minutes before the start of PCI)
  • maitaining dosage: 10 ug/min IV for 18- 24h(concluding one hour after the PCI)

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

Myocardial ischemia
  • Recommendation
  • initial dosage: 0.25 mg/kg IV bolus (over 5 minutes)
  • maitaing dosage: 10 ug/min IV (continued for 12 hours unless complications developed)

Non–Guideline-Supported Use

Acute myocardial infarction
  • Dosing information
  • initial dosage: 0.25 mg/kg IV bolus
  • maitaing dosage: 10 ug/min IV for 12h [1]
Acute arterial thrombosis
  • Dosing information
  • initial dosage: 0.25 mg/kg IV bolus
  • maitaing dosage: 10 ug/min IV for 12h [2]
Cerebrovascular accident
  • Dosing information
  • initial dosage: 0.25 mg/kg IV bolus
  • maitaing dosage: 10 ug/min IV for 12h [3]
Myocardial infarction
  • Dosing information
  • initial dosage: 0.25 mg/kg IV bolus
  • maitaing dosage: 10 ug/min IV for 12h [4]
Prophylaxis of myocardial ischemia
  • Dosing information
  • initial dosage: 0.25 mg/kg IV bolus
  • maitaing dosage: 10 ug/min IV for 12h

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

There is limited information regarding Sandbox Abciximab FDA-Labeled Indications and Dosage (Pediatric) in the drug label.

Off-Label Use and Dosage (Pediatric)

Non–Guideline-Supported Use

Aneurysm of coronary vessels
  • Dosing information
  • loading dose: 0.25 mg/kg IV
  • follow-up: 0.125 mg/min IV for 12h [5]

Contraindications

There is limited information regarding Sandbox Abciximab Contraindications in the drug label.

Warnings

There is limited information regarding Sandbox Abciximab Warnings' in the drug label.

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Sandbox Abciximab Clinical Trials Experience in the drug label.

Postmarketing Experience

There is limited information regarding Sandbox Abciximab Postmarketing Experience in the drug label.

Drug Interactions

There is limited information regarding Sandbox Abciximab Drug Interactions in the drug label.

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA): There is no FDA guidance on usage of Sandbox Abciximab in women who are pregnant.
Pregnancy Category (AUS): There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Sandbox Abciximab in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Sandbox Abciximab during labor and delivery.

Nursing Mothers

There is no FDA guidance on the use of Sandbox Abciximab in women who are nursing.

Pediatric Use

There is no FDA guidance on the use of Sandbox Abciximab in pediatric settings.

Geriatic Use

There is no FDA guidance on the use of Sandbox Abciximab in geriatric settings.

Gender

There is no FDA guidance on the use of Sandbox Abciximab with respect to specific gender populations.

Race

There is no FDA guidance on the use of Sandbox Abciximab with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Sandbox Abciximab in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Sandbox Abciximab in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Sandbox Abciximab in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Sandbox Abciximab in patients who are immunocompromised.

Administration and Monitoring

Administration

There is limited information regarding Sandbox Abciximab Administration in the drug label.

Monitoring

There is limited information regarding Sandbox Abciximab Monitoring in the drug label.

IV Compatibility

There is limited information regarding the compatibility of Sandbox Abciximab and IV administrations.

Overdosage

There is limited information regarding Sandbox Abciximab overdosage. If you suspect drug poisoning or overdose, please contact the National Poison Help hotline (1-800-222-1222) immediately.

Pharmacology

There is limited information regarding Sandbox Abciximab Pharmacology in the drug label.

Mechanism of Action

There is limited information regarding Sandbox Abciximab Mechanism of Action in the drug label.

Structure

There is limited information regarding Sandbox Abciximab Structure in the drug label.

Pharmacodynamics

There is limited information regarding Sandbox Abciximab Pharmacodynamics in the drug label.

Pharmacokinetics

There is limited information regarding Sandbox Abciximab Pharmacokinetics in the drug label.

Nonclinical Toxicology

There is limited information regarding Sandbox Abciximab Nonclinical Toxicology in the drug label.

Clinical Studies

There is limited information regarding Sandbox Abciximab Clinical Studies in the drug label.

How Supplied

There is limited information regarding Sandbox Abciximab How Supplied in the drug label.

Storage

There is limited information regarding Sandbox Abciximab Storage in the drug label.

Images

Drug Images

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Package and Label Display Panel

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Patient Counseling Information

There is limited information regarding Sandbox Abciximab Patient Counseling Information in the drug label.

Precautions with Alcohol

Alcohol-Sandbox Abciximab interaction has not been established. Talk to your doctor regarding the effects of taking alcohol with this medication.

Brand Names

There is limited information regarding Sandbox Abciximab Brand Names in the drug label.

Look-Alike Drug Names

There is limited information regarding Sandbox Abciximab Look-Alike Drug Names in the drug label.

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.