Aortic regurgitation resident survival guide

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Alejandro Lemor, M.D. [2]

Aortic Regurgitation Resident Survival Guide Microchapters
Overview
Causes
FIRE
Diagnosis Acute Chronic
Treatment Acute Chronic Type of Valve and Anticoagulation
Do's
Don'ts

Overview

Aortic regurgitation (AR) refers to the retrograde or backward flow of blood from the aorta into the left ventricle during diastole. The presentation depends on the response and adaptability of the left ventricle to the increased diastolic volume. In chronic AR the left ventricle has adapted by dilatation of its walls, however, in acute AR a rapid increase in the diastolic volume is not tolerated by a normal size ventricle and this could lead to cardiogenic shock. The most common causes of acute aortic regurgitation are aortic dissection and infective endocarditis, and the preferred treatment in both cases is surgical intervention. The most common cause of chronic AR is bicuspid aortic valve and the treatment will depend on the stage of the disease. Acute AR is a life-threatening condition and must be recognized and treated promptly.

Causes

Life Threatening Causes

Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.

• Aortic dissection
• Infective endocarditis

Common Causes

• Bicuspid aortic valve
• Senile or degenerative calcific aortic valve disease
• Hypertension
• Idiopathic dilatation of the aorta
• Myxomatous degeneration
• Rheumatic fever

Click here for the complete list of causes.

FIRE: Focused Initial Rapid Evaluation

A Focused Initial Rapid Evaluation (FIRE) should be performed to identify patients in need of immediate intervention. The algorithm below is based on the 2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease.

Boxes in salmon color signify that an urgent management is needed.

Abbreviations: ECG: Electrocardiogram; MAP: Mean arterial pressure ; P2: Second heart sound, pulmonary component; S1: First heart sound; S3: Third heart sound; TTE: Transthoracic echocardiography; TEE: Transesophageal echocardiography

Identify cardinal findings that increase the pretest probability of aortic regurgitation Acute aortic regurgitation ❑ Low pitched early diastolic murmur ❑ Best heard at the right 2nd intercostal space ❑ Decreased or absent S1 ❑ Increased P2 ❑ Sudden onset of dyspnea Chronic aortic regurgitation ❑ High pitched holodiastolic decrescendo murmur ❑ Best heard at the upper left sternal border ❑ Increases with sitting forward, expiration and handgrip ❑ Wide pulse pressure (≥ 60 mmHg) ❑ Presence of S3 ❑ Corrigan's pulse: a rapid upstroke and collapse of the carotid artery pulse

Does the patient have any findings of cardiogenic shock that require urgent management? ❑ Tachycardia ❑ Hypotension ❑ Altered mental status ❑ Tachypnea ❑ Oliguria ❑ Cold extremities

YES

NO

Proceed to the complete diagnostic approach below

Initiate resuscitation measures: ❑ Secure airway ❑ Administer oxygen ❑ Secure wide bore IV access ❑ Perform ECG monitor ❑ Monitor vitals continuously ❑ Admit to ICU Initiate medical therapy to treat cardiogenic shock: ❑ Administer nitroprusside 0.3-0.5 υg/kg/min IV (max 10 υg/kg/min), AND ❑ Administer dobutamine 0.5 υg/kg/min IV (max 20 υg/kg/min) ❑ Titrate to maintain MAP > 60 mmHg ❑ Administer beta blockers in high suspicion of aortic dissection Do not use beta blockers for other causes as they will block the compensatory tachycardia Order urgent TTE: ❑ Confirm aortic regurgitation ❑ Look for additional findings according to etiology: ❑ Vegetations on the leaflets ❑ Aortic root dissection ❑ In high suspicion of aortic dissection or when TTE is nondiagnostic, perform a TEE Do not perform percutaneous aortic balloon counterpulsation (it will increase the diastolic pressure and the regurgitant volume)

Click here for cardiogenic shock resident survival guide

What is the etiology of aortic regurgitation based on clinical findings and echocardiography?

Type A aortic dissection Diagnostic clues: ❑ Chest pain of the following characteristics: ❑ Sudden onset ❑ Intense ❑ Tearing and sharp ❑ Worsened by deep breathing or cough ❑ Relieved by sitting upright ❑ Unexplained syncope ❑ Low pitched early diastolic murmur ❑ Best heard at the right 2nd intercostal space ❑ Aortic root dissection found on TTE ❑ Previous history of: ❑ Marfan syndrome ❑ Connective tissue disorder

Infective endocarditis Diagnostic clues: ❑ Persistent fever ❑ New valvular regurgitation murmur ❑ Previous blood culture positive ❑ Vegetations found on TTE ❑ High risk factors: ❑ Pre-existing cardiac abnormality ❑ Prosthetic valve ❑ Recent surgical or medical procedures ❑ Intravenous drug use ❑ Recent bacterial infection ❑ History of previous endocarditis ❑ Order blood cultures (if they have not been previously ordered) ❑ Evaluate the modified Duke criteria (click here to see)

Symptomatic severe chronic AR Diagnostic clues: ❑ No TTE findings of aortic dissection or leaflet vegetations ❑ Previous history of aortic valve disease ❑ High pitched holodiastolic decrescendo murmur ❑ Best heard at the upper left sternal border ❑ Increases with sitting forward, expiration and handgrip ❑ Wide pulse pressure (≥ 60 mmHg) ❑ S3 ❑ Corrigan's pulse: a rapid upstroke and collapse of the carotid artery pulse

❑ Immediate surgical intervention

❑ Immediate surgical intervention

Proceed to the complete diagnostic approach below

Click here for aortic dissection resident survival guide

Click here for infective endocarditis resident survival guide

Complete Diagnostic Approach

A complete diagnostic approach should be carried out after a focused initial rapid evaluation is conducted and following initiation of any urgent intervention.

Abbreviations: BP: Blood pressure; CXR: Chest X-ray; ECG: Electrocardiogram; LV: Left ventricle; MI: Myocardial infarction; TTE: Transthoracic echocardiography; TEE: Transesophageal echocardiography; TAVR: Transcatheter aortic valve replacement; S1: First heart sound; S2: Second heart sound; S3: Third heart sound; CBC: Complete blood count ; ESR: Erythrocyte sedimentation rate

Acute Aortic Regurgitation

Shown below is a complete diagnostic approach for acute aortic regurgitation based on the 2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease.

Characterize the symptoms: ❑ Sudden and severe dyspnea ❑ Palpitations ❑ Altered mental status ❑ Cold extremities ❑ Oliguria Symptoms suggestive of aortic dissection ❑ Chest pain ❑ Sudden onset ❑ Intense ❑ Tearing and sharp ❑ Interscapular ❑ Worsened by deep breathing or cough ❑ Relieved by sitting upright ❑ Unexplained syncope Symptoms suggestive of infective endocarditis ❑ Fever ❑ Sweats ❑ Fatigue ❑ Pleuritic chest pain ❑ Back pain ❑ Weakness ❑ Myalgias

Inquire about past medical history: Suggestive of infective endocarditis ❑ Bicuspid aortic valve ❑ Rheumatic fever ❑ Prosthetic valves ❑ Intravenous drug use ❑ Substances used in the mixture ❑ Sharing the equipment ❑ The process of cleaning the equipment ❑ Previous infective endocarditis Suggestive of aortic dissection ❑ Hypertension ❑ Marfan syndrome ❑ Connective tissue disorder

Examine the patient: Vitals ❑ Temperature ❑ Fever (suggestive of infective endocarditis) ❑ Heart rate ❑ Tachycardia ❑ Blood pressure ❑ Asymmetric blood pressure in the upper extremities ❑ Hypertension (suggestive of aortic dissection) ❑ Hypotension (suggestive of severe regurgitation or aortic dissection) ❑ Respiratory rate ❑ Tachypnea Cardiovascular examination ❑ Weak pulses ❑ Jugular venous distension ❑ Cardiac auscultation ❑ Murmur ❑ Low pitched early diastolic murmur (may be absent) ❑ Best heard at the right 2nd intercostal space in aortic dissection ❑ Heart sounds ❑ Decreased or absent S1 ❑ Increased P2 (suggestive of pulmonary hypertension) ❑ S3 and S4 may be present ❑ Apical diastolic rumble Respiratory examination ❑ Rales (suggestive of pulmonary congestion) ❑ Wheeze

Order labs and tests: ❑ TTE (most important test) (Class I; Level of Evidence: B) ❑ In high suspicion of aortic dissection, perform a TEE ❑ Chest X-ray ❑ Increased cardiac silhouette (suggestive of aortic dissection) ❑ Widened mediastinum (suggestive of aortic root dilation) ❑ Pulmonary congestion (suggestive of pulmonary edema or pulmonary hypertension) ❑ ECG ❑ Nonspecific changes of ST and T wave (due to LV enlargement) ❑ Right coronary artery ischemic changes (suggestive of aortic dissection) ❑ ST elevation in II, III, aVF (Inferior MI) ❑ ST elevation in V3R and V4R (Right ventricle MI) ❑ ST depression in V1-V3 (Posterior MI) ❑ Blood culture (if suspected infective endocarditis) ❑ CBC ❑ ESR ❑ Cardiac enzymes (Troponin, CK-MB)

Determine the etiology of the acute aortic regurgitation

Aortic dissection Diagnostic clues: ❑ Chest pain of the following characteristics: ❑ Sudden onset ❑ Intense ❑ Tearing and sharp ❑ Worsened by deep breathing or cough ❑ Relieved by sitting upright ❑ Syncope ❑ Low pitched early diastolic murmur ❑ Best heard at the right 2nd intercostal space ❑ Previous history of: ❑ Marfan syndrome ❑ Connective tissue disorder Click here for aortic dissection resident survival guide

Infective endocarditis Diagnostic clues: ❑ Persistent fever ❑ New valvular regurgitation murmur ❑ Positive blood culture ❑ Vegetations found on TTE ❑ High risk factors: ❑ Pre-existing cardiac abnormality ❑ Prosthetic valve ❑ Recent surgical or medical procedures ❑ Intravenous drug use ❑ Recent bacterial infection ❑ History of previous endocarditis ❑ Evaluate the modified Duke criteria (click here to see) Click here for infective endocarditis resident survival guide

Other causes ❑ Complication of: ❑ TAVR ❑ Percutaneous aortic balloon dilation ❑ Prosthetic valve dysfunction ❑ Blunt chest trauma

Chronic Aortic Regurgitation

Shown below is a complete diagnostic approach for chronic aortic regurgitation based on the 2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease.

Characterize the symptoms: ❑ Asymptomatic ❑ Dyspnea on exertion ❑ Orthopnea ❑ Paroxysmal nocturnal dyspnea ❑ Palpitations ❑ Chest pain ❑ Shortness of breath ❑ Cough ❑ Altered mental status ❑ Syncope ❑ Fatigue

Inquire about past medical history: ❑ Cardiac disease: ❑ Hypertension ❑ Bicuspid aortic valve ❑ Rheumatic fever ❑ Pulmonary disease ❑ Trauma ❑ Syphilis ❑ Ankylosing spondylitis ❑ Acromegaly ❑ Marfan syndrome ❑ Ehlers-Danlos syndrome ❑ Giant cell arteritis ❑ Takayasu's arteritis ❑ Previous cardiac surgery

Examine the patient: Vitals ❑ Heart rate: ❑ Tachycardia (suggestive of reduced stroke volume) ❑ Blood pressure: ❑ Wide pulse pressure (≥ 60 mmHg) Cardiovascular examination ❑ Pulses ❑ Corrigan's pulse: a rapid upstroke and collapse of the carotid artery pulse ❑ Cardiac auscultation ❑ Murmur ❑ High pitched holodiastolic decrescendo murmur ❑ Best heard at the upper left sternal border ❑ Murmur increases with sitting forward, expiration and handgrip ❑ Austin Flint murmur: a soft mid-diastolic rumble, best heard at the cardiac apex (suggestive of severe regurgitation) ❑ Heart sounds ❑ S2: decreased or absent A2; normal P2 ❑ S3 may be present (suggestive of left ventricular dysfunction) ❑ S4 may also be present ❑ Search for other characteristic signs suggestive of aortic regurgitation ❑ Traube's sign: 'pistol shot' pulse heard over the femoral artery ❑ Müller's sign: systolic pulsations of uvula ❑ de Musset's sign: head bobbing with each heart beat ❑ Hill's sign: ≥ 20 mmHg difference in popliteal and brachial systolic cuff pressures (suggestive of chronic severe AR) ❑ Quincke's sign: pulsation of the capillary bed in the nail Respiratory examination ❑ Rales (seen when congestive heart failure has developed)

Order imaging studies: ❑ TTE (most important evaluation test) (Class I; Level of Evidence: B) ❑ Chest X-ray ❑ Increased cardiac silhouette (suggestive of LV dilatation) ❑ Widened mediastinum (suggestive of aortic root dilation) ❑ Pulmonary congestion (suggestive of HF) ❑ ECG ❑ Nonspecific changes of ST and T wave (due to LV dilatation)

Classify aortic regurgitation based on the following findings on TTE: ❑ Vena contracta ❑ Jet/LVOT ❑ Regurgitant volume ❑ Regurgitant fraction ❑ Effective regurgitant orifice

Risk of aortic regurgitation (Stage A) ❑ No regurgitation

Mild (Stage B) ❑ Vena contracta <0.3 cm ❑ Jet/LVOT <25% ❑ Regurgitant volume <30 mL/beat ❑ Regurgitant fraction <30% ❑ Effective regurgitant orifice <0.10 cm²

Moderate (Stage B) ❑ Vena contracta 0.3-0.6 cm ❑ Jet/LVOT 25-64% ❑ Regurgitant volume 30-59 mL/beat ❑ Regurgitant fraction 30-49% ❑ Effective regurgitant orifice 0.10-0.29 cm²

Severe ❑ Vena contracta >0.6 cm ❑ Jet/LVOT ≥ 65% ❑ Regurgitant volume ≥60 mL/beat ❑ Regurgitant fraction ≥50% ❑ Effective regurgitant orifice ≥ 0.30 cm² ❑ Holodiastolic flow reversal in the proximal abdominal aorta

Asymptomatic Stage C1 ❑ Normal LVEF ❑ Mild to moderate dilatation Stage C2 ❑ LV systolic dysfunction ❑ Decreased LVEF or severe LV dilatation

Symptomatic (Stage D) ❑ Normal or decreased LV systolic function ❑ Moderate to severe LV dilatation

Treatment

Treatment of Acute Aortic Regurgitation

Shown below is an algorithm for the treatment of acute aortic regurgitation according to the 2014 AHA/ACC Guidelines for the Management of Valvular Heart Disease and the 2010 ACCF/AHA Guidelines for the Diagnosis and Management of Patients With Thoracic Aortic Disease

Determine the etiology and the grade of regurgitation

Infective endocarditis

Type A aortic dissection

Mild to moderate regurgitation Vena contracta < 0.6 cm Jet/LVOT < 65%

Severe regurgitation Vena contracta > 0.6 cm Jet/LVOT ≥ 65%

Mild to moderate regurgitation Vena contracta < 0.6 cm Jet/LVOT < 65%

Severe regurgitation Vena contracta > 0.6 cm Jet/LVOT ≥ 65%

Does the patient has any of the following? ❑ S.aureus infection ❑ Fungal infection ❑ Large vegetation

Replacement of supra-coronary ascending aorta

Aortic root replacement, OR Valve-sparing aortic root replacement

No

Yes

❑ Initiate antibiotic treatment Click here for a complete list of pathogen specific antibiotics regimens

❑ Schedule for AVR (Class I; Level of Evidence: B)

If the patient does not get better after 5-7 days: ❑ Schedule for AVR (Class I; Level of Evidence: B)

Treatment of Chronic Aortic Regurgitation

Shown below is an algorithm summarizing the treatment approach to chronic aortic regurgitation according to the 2014 AHA/ACC Guidelines on the Management of Valvular Heart Disease.

Abbreviations: TTE: transthoracic echocardiography; AVR: aortic valve replacement; CCB: calcium channel blocker; ACE: angiotensin converting enzyme; ARB: angiotensin receptor blocker

What is the stage of aortic regurgitation according to the TTE?

No regurgitation (Stage A)

Progressive regurgitation (Stage B) Mild ❑ Vena contracta <0.3 cm ❑ Jet/LVOT <25% ❑ Regurgitant volume <30 mL/beat ❑ Regurgitant fraction <30% ❑ Effective regurgitant orifice <0.10 cm² Moderate ❑ Vena contracta 0.3-0.6 cm ❑ Jet/LVOT 25-64% ❑ Regurgitant volume 30-59 mL/beat ❑ Regurgitant fraction 30-49% ❑ Effective regurgitant orifice 0.10-0.29 cm²

Severe regurgitation ❑ Vena contracta >0.6 cm ❑ Jet/LVOT ≥ 65% ❑ Regurgitant volume ≥60 mL/beat ❑ Regurgitant fraction ≥50% ❑ Effective regurgitant orifice ≥ 0.30 cm² ❑ Holodiastolic flow reversal in the proximal abdominal aorta

Is the patient symptomatic?

Asymptomatic patients ❑ Normal valve ❑ Bicuspid valve ❑ Sclerotic valve

Asymptomatic patients ❑ Control hypertension preferably with ❑ Dihydropyridine CCB, or ❑ ACE inhibitors or ARBs (Class I; Level of Evidence: B)

NO (Stage C)

YES (Stage D)

❑ No treatment is needed

❑ Perform a periodic echo (Class I; Level of Evidence:B) ❑ Every 3 -5 years for mild regurgitation ❑ Every 1 - 2 years for moderate regurgitation

Stage C1 ❑ Normal LVEF ❑ Mild to moderate dilatation

Stage C2 ❑ LV systolic dysfunction, and ❑ Decreased LVEF, or ❑ Severe LV dilatation

If patient undergoes another cardiac surgery: ❑ Schedule for AVR (Class IIa; Level of Evidence: C)

❑ Perform a periodic echocardiogram every 6 - 12 months (Class I; Level of Evidence: B) ❑ Perform an exercise stress test

Does the patient has any contraindications for surgery?

Did the patient developed symptoms in the stress test?

YES

NO

YES

NO

Initiate medical therapy with ❑ ACE inhibitors, or ❑ ARBs, and/or ❑ Beta blockers

❑ Schedule for AVR (Class I; Level of Evidence: B)

Initiate medical therapy with vasodilators ❑ Nifedipine 30-60 mg/day, OR ❑ Hydralazine 10-25 mg/ q8hrs

❑ No treatment is needed

If the patient undergoes another cardiac surgery: ❑ Schedule for AVR (Class IIa; Level of Evidence: C)

Type of Valve and Discharge Anticoagulation Therapy

Abbreviations: AVR: Aortic valve replacement; INR: International normalized ratio; TAVR Tansthoracic aortic valve replacement

Determine: ❑ Age ❑ Contraindications for anticoagulation ❑ Major bleeding diathesis or coagulopathy ❑ Uncontrolled severe hypertension (systolic blood pressure >200 mmHg) ❑ Recent head trauma ❑ Platelet count < 100 000 ❑ Pregnancy ❑ Hypersensitivity to warfarin ❑ Hemorrhagic stroke

❑ Patients ≤ 60 years old (Class IIa; Level of Evidence: B), AND ❑ No contraindication for anticoagulation

❑ Patients 60 - 70 years old ❑ No contraindication for anticoagulation

❑ Patients ≥ 70 years old (Class IIa; Level of Evidence: B), OR ❑ Patients with contraindications for anticoagulation therapy (Class I; Level of Evidence: C)

Mechanical Prosthesis Avoid the use of direct thrombin inhibitors or anti-Xa agents in patients with mechanical prosthesis (Class III; Level of Evidence: B)

Either a bioprosthesic or mechanical valve is reasonable (Class IIa; Level of Evidence: B).

Bioprosthesis

Patient with risk factors†

Patient without risk factors†

Surgical AVR

TAVR

Administer for long term: ❑ Warfarin to achieve INR of 3.0 ❑ Aspirin 75-100 mg/d

Administer for long term: ❑ Warfarin to achieve INR of 2.5 ❑ Aspirin 75-100 mg/d

❑ Administer warfarin to achieve INR of 2.5 for 3 months ❑ Then administer aspirin 75-100 mg/d long term

Administer for 6 months: ❑ Clopidogrel 75 mg/d ❑ Aspirin 75-100 mg/d

†Risk factors for thromboembolism include atrial fibrillation, hypercoagulable conditions, left ventricle dysfunction, and previous thromboembolism.

Do's

• Perform a cardiac MRI in patients with moderate or severe AR with an inconclusive TTE to assess LV systolic function, systolic and diastolic volumes, and measurement of AR severity (Class I; Level of Evidence: B).
  

• Perform exercise stress test to assess symptomatic status and functional capacity of patients with severe aortic regurgitation.
  

• It is reasonable to perform AVR in patients with moderate AR that will undergo CABG, surgery on the ascending aorta, or mitral valve surgery (Class IIa; Level of Evidence: C).
  

• Perform a transthoracic echocardiography (TTE) after aortic valve replacement to evaluate the valve hemodynamics (Class I; Level of Evidence: B).

• Perform a TTE when clinical symptoms or signs suggest prosthetic valve dysfunction (Class I; Level of Evidence: C).

• Perform a colonoscopy in patients with infective endocarditis with blood cultures positive for S. bovis.

Don'ts

• Do not use beta blockers in aortic regurgitation that is not caused by aortic dissection as it will block the compensatory tachycardia.
  

• Do not use intra-aortic balloon counterpulsation in severe acute aortic regurgitation as it will increase the aortic diastolic pressure and the regurgitant volume.
  

• Do not give antibiotics to patients with known aortic regurgitation before blood cultures are obtained for unexplained fever. (Class III; Level of Evidence: C)
  

• Do not give ACE inhibitors to pregnant patients with aortic regurgitation. (Class III; Level of Evidence: B)
  

References

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