Chlorthalidone
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Gerald Chi
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Overview
Chlorthalidone is a thiazide-like diuretic that is FDA approved for the {{{indicationType}}} of hypertension and edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. Common adverse reactions include dizziness, lightheadedness, and hyperuricemia.
Adult Indications and Dosage
FDA-Labeled Indications and Dosage (Adult)
Condition1
- Dosing Information
- Dosage
Condition2
- Dosing Information
- Dosage
Condition3
- Dosing Information
- Dosage
Condition4
- Dosing Information
- Dosage
Off-Label Use and Dosage (Adult)
Guideline-Supported Use
Condition1
- Developed by:
- Class of Recommendation:
- Strength of Evidence:
- Dosing Information
- Dosage
Condition2
There is limited information regarding Off-Label Guideline-Supported Use of Chlorthalidone in adult patients.
Non–Guideline-Supported Use
Condition1
- Dosing Information
- Dosage
Condition2
There is limited information regarding Off-Label Non–Guideline-Supported Use of Chlorthalidone in adult patients.
Pediatric Indications and Dosage
FDA-Labeled Indications and Dosage (Pediatric)
Condition1
- Dosing Information
- Dosage
Condition2
There is limited information regarding FDA-Labeled Use of Chlorthalidone in pediatric patients.
Off-Label Use and Dosage (Pediatric)
Guideline-Supported Use
Condition1
- Developed by:
- Class of Recommendation:
- Strength of Evidence:
- Dosing Information
- Dosage
Condition2
There is limited information regarding Off-Label Guideline-Supported Use of Chlorthalidone in pediatric patients.
Non–Guideline-Supported Use
Condition1
- Dosing Information
- Dosage
Condition2
There is limited information regarding Off-Label Non–Guideline-Supported Use of Chlorthalidone in pediatric patients.
Contraindications
- Condition1
Warnings
Description
Adverse Reactions
Clinical Trials Experience
There is limited information regarding Clinical Trial Experience of Chlorthalidone in the drug label.
Central Nervous System
Cardiovascular
Respiratory
Gastrointestinal
Hypersensitivity
Miscellaneous
Postmarketing Experience
There is limited information regarding Postmarketing Experience of Chlorthalidone in the drug label.
Central Nervous System
Cardiovascular
Respiratory
Gastrointestinal
Hypersensitivity
Miscellaneous
Drug Interactions
- Drug
- Description
Use in Specific Populations
Pregnancy
- Pregnancy Category B
- Australian Drug Evaluation Committee (ADEC) Pregnancy Category C
There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Chlorthalidone in women who are pregnant.
Labor and Delivery
There is no FDA guidance on use of Chlorthalidone during labor and delivery.
Nursing Mothers
There is no FDA guidance on the use of Chlorthalidone with respect to nursing mothers.
Pediatric Use
There is no FDA guidance on the use of Chlorthalidone with respect to pediatric patients.
Geriatic Use
There is no FDA guidance on the use of Chlorthalidone with respect to geriatric patients.
Gender
There is no FDA guidance on the use of Chlorthalidone with respect to specific gender populations.
Race
There is no FDA guidance on the use of Chlorthalidone with respect to specific racial populations.
Renal Impairment
There is no FDA guidance on the use of Chlorthalidone in patients with renal impairment.
Hepatic Impairment
There is no FDA guidance on the use of Chlorthalidone in patients with hepatic impairment.
Females of Reproductive Potential and Males
There is no FDA guidance on the use of Chlorthalidone in women of reproductive potentials and males.
Immunocompromised Patients
There is no FDA guidance one the use of Chlorthalidone in patients who are immunocompromised.
Administration and Monitoring
Administration
Oral
Intravenous
Monitoring
There is limited information regarding Monitoring of Chlorthalidone in the drug label.
Condition1
Description
IV Compatibility
There is limited information regarding IV Compatibility of Chlorthalidone in the drug label.
Overdosage
Acute Overdose
Signs and Symptoms
Description
Management
Description
Chronic Overdose
There is limited information regarding Chronic Overdose of Chlorthalidone in the drug label.
Pharmacology
| |
| |
1 : 1 mixture (racemate)Chlortalidone
| |
| Systematic (IUPAC) name | |
| (RS)-2-Chloro-5-(1-hydroxy-3-oxo-2,3-dihydro-1H-isoindol-1-yl)benzene-1-sulfonamide | |
| Identifiers | |
| CAS number | |
| ATC code | C03 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | Template:OrganicBox atomTemplate:OrganicBox atomTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBox atomTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBox atomTemplate:OrganicBoxTemplate:OrganicBox atomTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBox atomTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBox |
| Mol. mass | 338.766 g/mol |
| SMILES | & |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Protein binding | 75% |
| Metabolism | ? |
| Half life | 40 hours |
| Excretion | Renal |
| Therapeutic considerations | |
| Pregnancy cat. | |
| Legal status | |
| Routes | Oral |
Mechanism of Action
There is limited information regarding Chlorthalidone Mechanism of Action in the drug label.
Structure
There is limited information regarding Structure of Chlorthalidone in the drug label.
Pharmacodynamics
There is limited information regarding Pharmacodynamics of Chlorthalidone in the drug label.
Pharmacokinetics
There is limited information regarding Pharmacokinetics of Chlorthalidone in the drug label.
Nonclinical Toxicology
There is limited information regarding Nonclinical Toxicology of Chlorthalidone in the drug label.
Clinical Studies
There is limited information regarding Clinical Studies of Chlorthalidone in the drug label.
Condition1
Description
How Supplied
There is limited information regarding Chlorthalidone How Supplied in the drug label.
Storage
There is limited information regarding Chlorthalidone Storage in the drug label.
Images
Drug Images
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Package and Label Display Panel
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Patient Counseling Information
There is limited information regarding Patient Counseling Information of Chlorthalidone in the drug label.
Precautions with Alcohol
Alcohol-Chlorthalidone interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.
Brand Names
Thalitone®[1]
Look-Alike Drug Names
- A® — B®[2]
Drug Shortage Status
Price
References
The contents of this FDA label are provided by the National Library of Medicine.
- ↑ "THALITONE (CHLORTHALIDONE) TABLET [MONARCH PHARMACEUTICALS, INC]". Retrieved 30 June 2014.
- ↑ "http://www.ismp.org". External link in
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