Insulin resistance historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
In the 1950's, research scientists Solomon Berson and Rosalyn Yalow developed a technique to measure circulating levels of hormones and other substances in the blood, called radioimmunoassay. Using this technique lead Berson and Yalow to discover that individuals with type 2 diabetes exhibited higher than average levels of circulating insulin than individuals with normal glucose tolerance.
Historical Perspective
The concept that insulin resistance may be the underlying cause of diabetes mellitus type 2 was first advanced by Sir Harold Percival Himsworth of the University College Hospital Medical Center in London in 1936.[1]
In the 1950's, research scientists Solomon Berson and Rosalyn Yalow developed a technique to measure circulating levels of hormones and other substances in the blood, called radioimmunoassay. Using this technique lead Berson and Yalow to discover that individuals with type 2 diabetes exhibited higher than average levels of circulating insulin than individuals with normal glucose tolerance.
References
- ↑ Himsworth HP (1936). "Diabetes mellitus: its differentiation into insulin-sensitive and insulin-insensitive types". Lancet. 1: 127&ndash, 130.