Insulin resistance historical perspective

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Dayana Davidis, M.D. [2]

Historical Perspective

The concept that insulin resistance may be the underlying cause of diabetes mellitus type 2 was first advanced by Sir Harold Percival Himsworth of the University College Hospital Medical Center in London in 1936.

In the 1950's, research scientists Solomon Berson and Rosalyn Yalow developed a technique to measure circulating levels of hormones and other substances in the blood, called radioimmunoassay. Using this technique lead Berson and Yalow to discover that individuals with type 2 diabetes exhibited higher than average levels of circulating insulin than individuals with normal glucose tolerance.