Benzatropine

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Benzatropine
	Error creating thumbnail: File missing
Clinical data
Pregnancy; category	US: C (Risk not ruled out) ; ;
Routes of; administration	oral, IM, IV
ATC code	N04AC01 (WHO) ;
Pharmacokinetic data
Elimination half-life	36 hours
Identifiers
	IUPAC name 3-benzhydryloxy-8-methyl-8-azabicyclo[3.2.1]octane;
CAS Number	86-13-5;
PubChem CID	1201549;
DrugBank	APRD00748;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C21H25NO
Molar mass	307.429 g/mol

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Benzatropine mesilate (INN, commonly known as benztropine; marketed as Cogentin) is an anticholinergic drug principally used for the treatment of:

Drug-induced parkinsonism, akathisia and acute dystonia;
Parkinson disease; and
Idiopathic or secondary dystonia.

Indications

It is used in patients with schizophrenia to reduce the side effects of antipsychotic treatment, such as parkinsonism and akathisia.

Benztropine is also a second-line drug for the treatment of Parkinson's disease. It improves tremor but not rigidity or bradykinesia.

Benztropine is also sometimes used for the treatment of dystonia, a rare disorder that causes abnormal muscle contraction, resulting in twisting postures of limbs, trunk, or face.

Side effects

These are principally anticholinergic:

Dry mouth
Blurred vision
Cognitive changes
Constipation
Urinary retention
Tachycardia
Anorexia
Psychosis (usually in overdose)

Some studies suggest that use of anticholinergics increases the risk of tardive dyskinesia, a long-term side effect of antipsychotics.^[1]^[2]

Other studies have found no association between anticholinergic exposure and risk of developing tardive dyskinesia.^[3]

Pill Images

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References

↑ "Arch Gen Psychiatry -- Abstract: Tardive dyskinesia: prevalence and risk factors, 1959 to 1979, April 1982, Kane and Smith 39 (4): 473". Retrieved 2007-08-14.
↑ Wszola BA, Newell KM, Sprague RL (2001). "Risk factors for tardive dyskinesia in a large population of youths and adults". Experimental and clinical psychopharmacology. 9 (3): 285–96. PMID 11534539.
↑ van Harten PN, Hoek HW, Matroos GE, Koeter M, Kahn RS (1998). "Intermittent neuroleptic treatment and risk for tardive dyskinesia: Curaçao Extrapyramidal Syndromes Study III". The American journal of psychiatry. 155 (4): 565–7. PMID 9546009.

Template:WikiDoc Sources

[1] "Arch Gen Psychiatry -- Abstract: Tardive dyskinesia: prevalence and risk factors, 1959 to 1979, April 1982, Kane and Smith 39 (4): 473". Retrieved 2007-08-14.

[pmid11534539-2] Wszola BA, Newell KM, Sprague RL (2001). "Risk factors for tardive dyskinesia in a large population of youths and adults". Experimental and clinical psychopharmacology. 9 (3): 285–96. PMID 11534539.

[pmid9546009-3] van Harten PN, Hoek HW, Matroos GE, Koeter M, Kahn RS (1998). "Intermittent neuroleptic treatment and risk for tardive dyskinesia: Curaçao Extrapyramidal Syndromes Study III". The American journal of psychiatry. 155 (4): 565–7. PMID 9546009.

[1]

[2]

[3]

v t e Anti-parkinson drugs: anticholinergic agents (N04A)
Tertiary amines	Trihexyphenidyl - Biperiden - Metixene - Procyclidine - Profenamine - Dexetimide - Phenglutarimide - Mazaticol - Bornaprine - Tropatepine
Ethers chemically close to antihistamines	Etanautine - Orphenadrine
Ethers of tropine or tropine derivatives	Benzatropine - Etybenzatropine

Benzatropine

Contents

Overview

Indications

Side effects

Pill Images

References

Navigation menu

Clinical data
Error creating thumbnail: File missing
Pregnancy category	US: C (Risk not ruled out)
Routes of administration	oral, IM, IV
ATC code	N04AC01 (WHO)
Pharmacokinetic data
Elimination half-life	36 hours
Identifiers
IUPAC name 3-benzhydryloxy-8-methyl-8-azabicyclo[3.2.1]octane
CAS Number	86-13-5
PubChem CID	1201549
DrugBank	APRD00748
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₂₁H₂₅NO
Molar mass	307.429 g/mol

Benzatropine

Overview

Indications

Side effects

Pill Images

References

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