WBR0430
| Author | [[PageAuthor::Rim Halaby, M.D. [1], Alison Leibowitz [2] (Reviewed by Alison Leibowitz)]] |
|---|---|
| Exam Type | ExamType::USMLE Step 1 |
| Main Category | MainCategory::Pathology |
| Sub Category | SubCategory::Hematology |
| Prompt | [[Prompt::A 78-year-old male presents to the physician’s office with complaints of back pain, which is not relieved by medications, and fatigue of several weeks duration. Evaluation reveals anemia, elevated levels of serum calcium, and renal insufficiency. A peripheral smear of the patient’s blood shows characteristic “rouleaux formation”, characteristic of multiple myeloma. Which of the following markers is most frequently used for the staging of multiple myeloma?]] |
| Answer A | AnswerA::BUN/Creatinine ratio |
| Answer A Explanation | [[AnswerAExp::A BUN/Creatinine ratio, not useful for staging multiple myeloma, aids in distinguishing between types of renal injury (pre-renal, instrinsic, or post-renal).]] |
| Answer B | AnswerB::β2 microglobulin and albumin levels |
| Answer B Explanation | AnswerBExp::Serum β2 microglobulin and albumin levels are used by the ISS for staging multiple myeloma. |
| Answer C | AnswerC::CA-125 level |
| Answer C Explanation | AnswerCExp::CA-125 levels are frequently checked in the follow-up of patients with ovarian cancer, but should not be used for diagnostic purposes. |
| Answer D | AnswerD::p53 and Retinoblastoma gene (Rb) activities |
| Answer D Explanation | AnswerDExp::The tumor suppressor genes, p53 and Rb, are inactivated in many cancers, but are not useful for staging multiple myeloma. |
| Answer E | AnswerE::Hemoglobin S levels |
| Answer E Explanation | AnswerEExp::Hemoglobin S levels, detected by hemoglobin electrophoresis, is used in the diagnosis of sickle cell disease. |
| Right Answer | RightAnswer::B |
| Explanation | [[Explanation::Multiple myeloma, a common hematologic cancer characterized by monoclonal gammopathy, frequently manifests with hypercalcemia, renal insufficiency, anemia, and lytic bone lesions (mnemonic: CRAB – Calcium, Renal, Anemia, Bone). Rouleaux formation on peripheral smear is also characteristic of multiple myeloma.
Multiple myeloma staging does not utilize the TNM system. Instead, the International Staging System (ISS) for multiple myeloma depends on levels of serum β2 microglobulin and albumin.
Stage I: Serum β2 microglobulin < 3.5 mg/L and serum albumin ≥ 3.5 g/dL
Stage II: Between stage I and III
Stage III: Serum β2 microglobulin ≥ 5.5 mg/L |
| Approved | Approved::Yes |
| Keyword | WBRKeyword::beta-2-microglobulin, WBRKeyword::albumin, WBRKeyword::multiplemyeloma, WBRKeyword::anemia, WBRKeyword::hypercalcemia, WBRKeyword::bone, WBRKeyword::renal, WBRKeyword::staging, WBRKeyword::ISS, WBRKeyword::rouleaux formation |
| Linked Question | Linked:: |
| Order in Linked Questions | LinkedOrder:: |