WBR0446

Author	[[PageAuthor::Rim Halaby, M.D. [1] (Reviewed by Alison Leibowitz)]]
Exam Type	ExamType::USMLE Step 1
Main Category	MainCategory::Pathology
Sub Category	SubCategory::Endocrine
Prompt	[[Prompt::A 45-year-old female who presents to the physician’s office with complaints of severe diarrhea of several days duration. The patient’s medical history is significant for recurrent kidney stones and parathyroidectomy. Her fasting gastrin level is elevated and endoscopy reveals multiple ulcers in the stomach, duodenum, and jejunum. Which of the following findings is the most likely present in this patient?]]
Answer A	AnswerA::Oral ganglioneuroma
Answer A Explanation	AnswerAExp::Oral ganglioneuromatosis frequently occurs in patients with MEN2B syndrome.
Answer B	AnswerB::Pheochromocytoma
Answer B Explanation	AnswerBExp::Pheochromocytoma frequently occurs in MEN 2A and MEN 2B syndromes.
Answer C	AnswerC::Medullary thyroid cancer
Answer C Explanation	AnswerCExp::Medullary thyroid cancer frequently occurs in MEN 2A and MEN 2B syndromes.
Answer D	AnswerD::Prolactinoma
Answer D Explanation	AnswerDExp::Prolactinoma, a pituitary tumor, frequently occurs in MEN I syndrome.
Answer E	AnswerE::Carcinoid tumor
Answer E Explanation	AnswerEExp::Carcinoid tumor is an endocrine tumor, but is not frequently associated with MEN syndrome.
Right Answer	RightAnswer::D
Explanation	[[Explanation::Men I syndrome is characterized by parathyroid tumors, pituitary tumors, which are usually prolactinoma or GH secreting tumors, and pancreatic endocrine tumors, such as gastrinoma, insulinoma, VIPoma, or glucagonoma. Educational Objective: MEN I syndrome often manifests with pituitary tumors, parathyroid tumors, or pancreatic endocrine tumors. References: ]]
Approved	Approved::Yes
Keyword	WBRKeyword::Prolactinoma, WBRKeyword::pheochromocytoma, WBRKeyword::gastrinoma, WBRKeyword::neoplasia, WBRKeyword::MEN I, WBRKeyword::Wermer tumor, WBRKeyword::diarrhea, WBRKeyword::ulcers
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