Arylacetamide deacetylase is an enzyme that in humans is encoded by the AADACgene.[1][2]
Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens[2]
References
↑Probst MR, Beer M, Beer D, Jeno P, Meyer UA, Gasser R (Sep 1994). "Human liver arylacetamide deacetylase. Molecular cloning of a novel esterase involved in the metabolic activation of arylamine carcinogens with high sequence similarity to hormone-sensitive lipase". J Biol Chem. 269 (34): 21650–6. PMID8063807.
Probst MR, Jenö P, Meyer UA (1991). "Purification and characterization of a human liver arylacetamide deacetylase". Biochem. Biophys. Res. Commun. 177 (1): 453–9. doi:10.1016/0006-291X(91)92005-5. PMID2043131.
Yamazaki K, Kusano K, Tadano K, Tanaka I (1997). "Radiation hybrid mapping of human arylacetamide deacetylase (AADAC) locus to chromosome 3". Genomics. 44 (2): 248–50. doi:10.1006/geno.1997.4879. PMID9299245.
Ozols J (1998). "Determination of lumenal orientation of microsomal 50-kDa esterase/N-deacetylase". Biochemistry. 37 (28): 10336–44. doi:10.1021/bi9807916. PMID9665742.
Mziaut H, Korza G, Hand AR, et al. (1999). "Targeting proteins to the lumen of endoplasmic reticulum using N-terminal domains of 11beta-hydroxysteroid dehydrogenase and the 50-kDa esterase". J. Biol. Chem. 274 (20): 14122–9. doi:10.1074/jbc.274.20.14122. PMID10318829.
Trickett JI, Patel DD, Knight BL, et al. (2001). "Characterization of the rodent genes for arylacetamide deacetylase, a putative microsomal lipase, and evidence for transcriptional regulation". J. Biol. Chem. 276 (43): 39522–32. doi:10.1074/jbc.M101764200. PMID11481320.
Saito S, Iida A, Sekine A, et al. (2003). "Catalog of 680 variations among eight cytochrome p450 ( CYP) genes, nine esterase genes, and two other genes in the Japanese population". J. Hum. Genet. 48 (5): 249–70. doi:10.1007/s10038-003-0021-7. PMID12721789.
Frick C, Atanasov AG, Arnold P, et al. (2004). "Appropriate function of 11beta-hydroxysteroid dehydrogenase type 1 in the endoplasmic reticulum lumen is dependent on its N-terminal region sharing similar topological determinants with 50-kDa esterase". J. Biol. Chem. 279 (30): 31131–8. doi:10.1074/jbc.M313666200. PMID15152005.
