AGTRAP

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Type-1 angiotensin II receptor-associated protein is a protein that in humans is encoded by the AGTRAP gene.

This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms.

Interactions

AGTRAP has been shown to interact with GNB2L1.

External links

• Human AGTRAP genome location and AGTRAP gene details page in the UCSC Genome Browser.

Further reading

• Daviet L, Lehtonen JY, Tamura K, et al. (1999). "Cloning and characterization of ATRAP, a novel protein that interacts with the angiotensin II type 1 receptor". J. Biol. Chem. 274 (24): 17058–62. doi:10.1074/jbc.274.24.17058. PMID 10358057.
• Cui T, Nakagami H, Iwai M, et al. (2001). "ATRAP, novel AT1 receptor associated protein, enhances internalization of AT1 receptor and inhibits vascular smooth muscle cell growth". Biochem. Biophys. Res. Commun. 279 (3): 938–41. doi:10.1006/bbrc.2000.4055. PMID 11162453.
• Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants". Mol. Vis. 8: 171–84. PMID 12107413.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Lopez-Ilasaca M, Liu X, Tamura K, Dzau VJ (2004). "The angiotensin II type I receptor-associated protein, ATRAP, is a transmembrane protein and a modulator of angiotensin II signaling". Mol. Biol. Cell. 14 (12): 5038–50. doi:10.1091/mbc.E03-06-0383. PMC 284805. PMID 12960423.
• Guo DF, Chenier I, Tardif V, et al. (2003). "Type 1 angiotensin II receptor-associated protein ARAP1 binds and recycles the receptor to the plasma membrane". Biochem. Biophys. Res. Commun. 310 (4): 1254–65. doi:10.1016/j.bbrc.2003.09.154. PMID 14559250.
• Guo DF, Tardif V, Ghelima K, et al. (2004). "A novel angiotensin II type 1 receptor-associated protein induces cellular hypertrophy in rat vascular smooth muscle and renal proximal tubular cells". J. Biol. Chem. 279 (20): 21109–20. doi:10.1074/jbc.M401544200. PMID 14985364.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Guo S, Lopez-Ilasaca M, Dzau VJ (2005). "Identification of calcium-modulating cyclophilin ligand (CAML) as transducer of angiotensin II-mediated nuclear factor of activated T cells (NFAT) activation". J. Biol. Chem. 280 (13): 12536–41. doi:10.1074/jbc.M500296200. PMID 15668245.
• Tanaka Y, Tamura K, Koide Y, et al. (2005). "The novel angiotensin II type 1 receptor (AT1R)-associated protein ATRAP downregulates AT1R and ameliorates cardiomyocyte hypertrophy". FEBS Lett. 579 (7): 1579–86. doi:10.1016/j.febslet.2005.01.068. PMID 15757644.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.