AIF1

Allograft inflammatory factor 1
PDB rendering based on 2d58.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2d58​, 2g2b​
Identifiers
Symbols	AIF1 ; AIF-1; IBA1; IRT-1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1226
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Allograft inflammatory factor 1, also known as AIF1, is a human gene.

This gene is induced by cytokines and interferon. Its protein product is thought to be involved in negative regulation of growth of vascular smooth muscle cells, which contributes to the anti-inflammatory response to vessel wall trauma. The gene expresses three transcripts.

Further reading

• Deininger MH, Meyermann R, Schluesener HJ (2002). "The allograft inflammatory factor-1 family of proteins". FEBS Lett. 514 (2–3): 115–21. PMID 11943136.CS1 maint: Multiple names: authors list (link)
• Jia J, Zhao YF, Zhao JH (2007). "Potential roles of allograft inflammatory factor-1 in the pathogenesis of hemangiomas". Med. Hypotheses. 68 (2): 288–90. doi:10.1016/j.mehy.2006.07.029. PMID 17010532.CS1 maint: Multiple names: authors list (link)
• Utans U, Arceci RJ, Yamashita Y, Russell ME (1995). "Cloning and characterization of allograft inflammatory factor-1: a novel macrophage factor identified in rat cardiac allografts with chronic rejection". J. Clin. Invest. 95 (6): 2954–62. PMID 7769138.CS1 maint: Multiple names: authors list (link)
• Iris FJ, Bougueleret L, Prieur S; et al. (1993). "Dense Alu clustering and a potential new member of the NF kappa B family within a 90 kilobase HLA class III segment". Nat. Genet. 3 (2): 137–45. doi:10.1038/ng0293-137. PMID 8499947.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Utans U, Quist WC, McManus BM; et al. (1996). "Allograft inflammatory factory-1. A cytokine-responsive macrophage molecule expressed in transplanted human hearts". Transplantation. 61 (9): 1387–92. PMID 8629302.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Autieri MV (1996). "cDNA cloning of human allograft inflammatory factor-1: tissue distribution, cytokine induction, and mRNA expression in injured rat carotid arteries". Biochem. Biophys. Res. Commun. 228 (1): 29–37. doi:10.1006/bbrc.1996.1612. PMID 8912632.
• Autieri MV, Agrawal N (1998). "IRT-1, a novel interferon-gamma-responsive transcript encoding a growth-suppressing basic leucine zipper protein". J. Biol. Chem. 273 (24): 14731–7. PMID 9614071.
• Neville MJ, Campbell RD (1999). "A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC". J. Immunol. 162 (8): 4745–54. PMID 10202016.
• Sasaki Y, Ohsawa K, Kanazawa H; et al. (2001). "Iba1 is an actin-cross-linking protein in macrophages/microglia". Biochem. Biophys. Res. Commun. 286 (2): 292–7. doi:10.1006/bbrc.2001.5388. PMID 11500035.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Autieri MV, Kelemen SE, Wendt KW (2003). "AIF-1 is an actin-polymerizing and Rac1-activating protein that promotes vascular smooth muscle cell migration". Circ. Res. 92 (10): 1107–14. doi:10.1161/01.RES.0000074000.03562.CC. PMID 12714565.CS1 maint: Multiple names: authors list (link)
• Deininger MH, Weinschenk T, Meyermann R, Schluesener HJ (2003). "The allograft inflammatory factor-1 in Creutzfeldt-Jakob disease brains". Neuropathol. Appl. Neurobiol. 29 (4): 389–99. PMID 12887599.CS1 maint: Multiple names: authors list (link)
• Mungall AJ, Palmer SA, Sims SK; et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xie T, Rowen L, Aguado B; et al. (2004). "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse". Genome Res. 13 (12): 2621–36. doi:10.1101/gr.1736803. PMID 14656967.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ohsawa K, Imai Y, Sasaki Y, Kohsaka S (2004). "Microglia/macrophage-specific protein Iba1 binds to fimbrin and enhances its actin-bundling activity". J. Neurochem. 88 (4): 844–56. PMID 14756805.CS1 maint: Multiple names: authors list (link)
• Chen X, Kelemen SE, Autieri MV (2005). "AIF-1 expression modulates proliferation of human vascular smooth muscle cells by autocrine expression of G-CSF". Arterioscler. Thromb. Vasc. Biol. 24 (7): 1217–22. doi:10.1161/01.ATV.0000130024.50058.de. PMID 15117732.CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Arvanitis DA, Flouris GA, Spandidos DA (2005). "Genomic rearrangements on VCAM1, SELE, APEG1and AIF1 loci in atherosclerosis". J. Cell. Mol. Med. 9 (1): 153–9. PMID 15784173.CS1 maint: Multiple names: authors list (link)
• Autieri MV, Chen X (2005). "The ability of AIF-1 to activate human vascular smooth muscle cells is lost by mutations in the EF-hand calcium-binding region". Exp. Cell Res. 307 (1): 204–11. doi:10.1016/j.yexcr.2005.03.002. PMID 15922740.