AM404

	WikiDoc Resources for AM404
Articles
Most recent articles on AM404 Most cited articles on AM404 Review articles on AM404 Articles on AM404 in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on AM404 Images of AM404 Photos of AM404 Podcasts & MP3s on AM404 Videos on AM404
Evidence Based Medicine
Cochrane Collaboration on AM404 Bandolier on AM404 TRIP on AM404
Clinical Trials
Ongoing Trials on AM404 at Clinical Trials.gov Trial results on AM404 Clinical Trials on AM404 at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on AM404 NICE Guidance on AM404 NHS PRODIGY Guidance FDA on AM404 CDC on AM404
Books
Books on AM404
News
AM404 in the news Be alerted to news on AM404 News trends on AM404
Commentary
Blogs on AM404
Definitions
Definitions of AM404
Patient Resources / Community
Patient resources on AM404 Discussion groups on AM404 Patient Handouts on AM404 Directions to Hospitals Treating AM404 Risk calculators and risk factors for AM404
Healthcare Provider Resources
Symptoms of AM404 Causes & Risk Factors for AM404 Diagnostic studies for AM404 Treatment of AM404
Continuing Medical Education (CME)
CME Programs on AM404
International
AM404 en Espanol AM404 en Francais
Business
AM404 in the Marketplace Patents on AM404
Experimental / Informatics
List of terms related to AM404

AM404
Legal status
Legal status	Metabolite of OTC drug;
Identifiers
	IUPAC name N-arachidonoylphenolamine;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C26H37NO2
Molar mass	395.59 g·mol−1

AM404 also known as N-arachidonoylphenolamine is an active metabolite of paracetamol (acetaminophen) responsible for all or part of its analgesic action.

Pharmacology

AM404 has been noted as an endogenous cannabinoid reuptake inhibitor, preventing the transport of anandamide and other related compounds back from the synaptic cleft, much in the same way that common SSRI antidepressants prevent the reuptake of serotonin. AM404 is also TRPV1 agonist, and also prevents cyclooxygenase COX-1 and COX-2 and prostaglandin synthesis. AM404 is thought to induce its analgesic action through its activity on the cannabinoid, COX and TRPV systems, all of which are present in pain and thermoregulatory pathways.^[1]

References

↑ Högestätt, E. D., B. A. G. Jönsson, A. Ermund, D. A. Andersson, H. Björk, J. P. Alexander, B. F. Cravatt, A. I. Basbaum, P. M. Zygmunt (September 9, 2005). "Conversion of Acetaminophen to the Bioactive N-Acylphenolamine AM404 via Fatty Acid Amide Hydrolase-dependent Arachidonic Acid Conjugation in the Nervous System". Journal of Biological Chemistry. 280 (36): 31405–31412. doi:10.1074/jbc.M501489200. Retrieved 2006-04-25. Check date values in: |date= (help)

Template:WikiDoc Sources

[1] Högestätt, E. D., B. A. G. Jönsson, A. Ermund, D. A. Andersson, H. Björk, J. P. Alexander, B. F. Cravatt, A. I. Basbaum, P. M. Zygmunt (September 9, 2005). "Conversion of Acetaminophen to the Bioactive N-Acylphenolamine AM404 via Fatty Acid Amide Hydrolase-dependent Arachidonic Acid Conjugation in the Nervous System". Journal of Biological Chemistry. 280 (36): 31405–31412. doi:10.1074/jbc.M501489200. Retrieved 2006-04-25. Check date values in: |date= (help)

[1]

Legal status

Legal status	Metabolite of OTC drug
Identifiers
IUPAC name N-arachidonoylphenolamine
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₂₆H₃₇NO₂
Molar mass	395.59 g·mol⁻¹

AM404

Pharmacology

References

Navigation menu

Search