ANXA4

Annexin A4
PDB rendering based on 1ann.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1ann​, 1aow​, 1i4a​
Identifiers
Symbols	ANXA4 ; ANX4; DKFZp686H02120; MGC75105; PIG28
External IDs	Template:OMIM5 Template:MGI HomoloGene: 68164
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Annexin A4, also known as ANXA4, is a human gene.

Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59% identity with other members of its family and shares a similar size and exon-intron organization. Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells.

Further reading

• Tait JF, Smith C, Frankenberry DA; et al. (1992). "Chromosomal mapping of the human annexin IV (ANX4) gene". Genomics. 12 (2): 313–8. PMID 1346776.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Römisch J, Heimburger N (1990). "Purification and characterization of six annexins from human placenta". Biol. Chem. Hoppe-Seyler. 371 (5): 383–8. PMID 2143074.
• Römisch J, Grote M, Weithmann KU; et al. (1991). "Annexin proteins PP4 and PP4-X. Comparative characterization of biological activities of placental and recombinant proteins". Biochem. J. 272 (1): 223–9. PMID 2148260.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Freemont PS, Driessen HP, Verbi W, Crumpton MJ (1991). "Crystallization and preliminary X-ray crystallographic studies of human placental annexin IV". J. Mol. Biol. 216 (2): 219–21. PMID 2254922.CS1 maint: Multiple names: authors list (link)
• Hauptmann R, Maurer-Fogy I, Krystek E; et al. (1989). "Vascular anticoagulant beta: a novel human Ca2+/phospholipid binding protein that inhibits coagulation and phospholipase A2 activity. Its molecular cloning, expression and comparison with VAC-alpha". Eur. J. Biochem. 185 (1): 63–71. PMID 2530088.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Grundmann U, Amann E, Abel KJ, Küpper HA (1988). "Isolation and expression of cDNA coding for a new member of the phospholipase A2 inhibitor family". Behring Inst. Mitt. (82): 59–67. PMID 2970257.CS1 maint: Multiple names: authors list (link)
• Ahn NG, Teller DC, Bienkowski MJ; et al. (1989). "Sedimentation equilibrium analysis of five lipocortin-related phospholipase A2 inhibitors from human placenta. Evidence against a mechanistically relevant association between enzyme and inhibitor". J. Biol. Chem. 263 (35): 18657–63. PMID 2974032.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tait JF, Sakata M, McMullen BA; et al. (1989). "Placental anticoagulant proteins: isolation and comparative characterization four members of the lipocortin family". Biochemistry. 27 (17): 6268–76. PMID 2975506.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sjölin C, Stendahl O, Dahlgren C (1994). "Calcium-induced translocation of annexins to subcellular organelles of human neutrophils". Biochem. J. 300 ( Pt 2): 325–30. PMID 8002935.CS1 maint: Multiple names: authors list (link)
• Kojima K, Yamamoto K, Irimura T; et al. (1996). "Characterization of carbohydrate-binding protein p33/41: relation with annexin IV, molecular basis of the doublet forms (p33 and p41), and modulation of the carbohydrate binding activity by phospholipids". J. Biol. Chem. 271 (13): 7679–85. PMID 8631806.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Davis AJ, Butt JT, Walker JH; et al. (1996). "The Ca2+-dependent lipid binding domain of P120GAP mediates protein-protein interactions with Ca2+-dependent membrane-binding proteins. Evidence for a direct interaction between annexin VI and P120GAP". J. Biol. Chem. 271 (40): 24333–6. PMID 8798684.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Satoh A, Takayama E, Kojima K; et al. (1997). "Expression of carbohydrate-binding protein p33/41 in human tumor cell lines". J. Biochem. 119 (2): 346–53. PMID 8882729.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Satoh A, Takayama E, Kojima K; et al. (1997). "Characterization of human p33/41 (annexin IV), a Ca2+ dependent carbohydrate-binding protein with monoclonal anti-annexin IV antibodies, AS11 and AS17". Biol. Pharm. Bull. 20 (3): 224–9. PMID 9084877.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dreier R, Schmid KW, Gerke V, Riehemann K (1998). "Differential expression of annexins I, II and IV in human tissues: an immunohistochemical study". Histochem. Cell Biol. 110 (2): 137–48. PMID 9720986.CS1 maint: Multiple names: authors list (link)
• Chow A, Davis AJ, Gawler DJ (2000). "Identification of a novel protein complex containing annexin VI, Fyn, Pyk2, and the p120(GAP) C2 domain". FEBS Lett. 469 (1): 88–92. PMID 10708762.CS1 maint: Multiple names: authors list (link)
• Han EK, Tahir SK, Cherian SP; et al. (2000). "Modulation of paclitaxel resistance by annexin IV in human cancer cell lines". Br. J. Cancer. 83 (1): 83–8. doi:10.1054/bjoc.2000.1311. PMID 10883672.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Radau B, Otto A, Müller EC, Westermann P (2001). "Protein kinase C alpha-dependent phosphorylation of Golgi proteins". Electrophoresis. 21 (13): 2684–7. doi:10.1002/1522-2683(20000701)21:13<2684::AID-ELPS2684>3.0.CO;2-G. PMID 10949146.CS1 maint: Multiple names: authors list (link)
• Gerner C, Frohwein U, Gotzmann J; et al. (2001). "The Fas-induced apoptosis analyzed by high throughput proteome analysis". J. Biol. Chem. 275 (50): 39018–26. doi:10.1074/jbc.M006495200. PMID 10978337.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tsujii-Hayashi Y, Kitahara M, Yamagaki T; et al. (2003). "A potential endogenous ligand of annexin IV in the exocrine pancreas. Carbohydrate structure of GP-2, a glycosylphosphatidylinositol-anchored glycoprotein of zymogen granule membranes". J. Biol. Chem. 277 (49): 47493–9. doi:10.1074/jbc.M206572200. PMID 12324456.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)