APOL1

Apolipoprotein L, 1
Identifiers
Symbols	APOL1 ; APO-L; APOL; APOL-I
External IDs	Template:OMIM5
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Apolipoprotein L, 1, also known as APOL1, is a human gene.

Apolipoprotein A-I is a relatively abundant plasma protein and is the major apoprotein of HDL. It is involved in the formation of most cholesteryl esters in plasma and also promotes efflux of cholesterol from cells. The protein encoded by this gene is a secreted high density lipoprotein which binds to apolipoprotein A-I. This apolipoprotein L family member may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Two transcript variants encoding two different isoforms have been found for this gene.

Further reading

• Duchateau PN, Pullinger CR, Orellana RE; et al. (1997). "Apolipoprotein L, a new human high density lipoprotein apolipoprotein expressed by the pancreas. Identification, cloning, characterization, and plasma distribution of apolipoprotein L.". J. Biol. Chem. 272 (41): 25576–82. PMID 9325276.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dunham I, Shimizu N, Roe BA; et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Duchateau PN, Movsesyan I, Yamashita S; et al. (2000). "Plasma apolipoprotein L concentrations correlate with plasma triglycerides and cholesterol levels in normolipidemic, hyperlipidemic, and diabetic subjects". J. Lipid Res. 41 (8): 1231–6. PMID 10946010.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Duchateau PN, Pullinger CR, Cho MH; et al. (2001). "Apolipoprotein L gene family: tissue-specific expression, splicing, promoter regions; discovery of a new gene". J. Lipid Res. 42 (4): 620–30. PMID 11290834.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Page NM, Butlin DJ, Lomthaisong K, Lowry PJ (2001). "The human apolipoprotein L gene cluster: identification, classification, and sites of distribution". Genomics. 74 (1): 71–8. doi:10.1006/geno.2001.6534. PMID 11374903.CS1 maint: Multiple names: authors list (link)
• Monajemi H, Fontijn RD, Pannekoek H, Horrevoets AJ (2002). "The apolipoprotein L gene cluster has emerged recently in evolution and is expressed in human vascular tissue". Genomics. 79 (4): 539–46. doi:10.1006/geno.2002.6729. PMID 11944986.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vanhamme L, Paturiaux-Hanocq F, Poelvoorde P; et al. (2003). "Apolipoprotein L-I is the trypanosome lytic factor of human serum". Nature. 422 (6927): 83–7. doi:10.1038/nature01461. PMID 12621437.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kang MK, Kameta A, Shin KH; et al. (2003). "Senescence-associated genes in normal human oral keratinocytes". Exp. Cell Res. 287 (2): 272–81. PMID 12837283.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Anderson NL, Polanski M, Pieper R; et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources". Mol. Cell Proteomics. 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lugli EB, Pouliot M, Portela Mdel P; et al. (2005). "Characterization of primate trypanosome lytic factors". Mol. Biochem. Parasitol. 138 (1): 9–20. doi:10.1016/j.molbiopara.2004.07.004. PMID 15500911.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Albert TS, Duchateau PN, Deeb SS; et al. (2005). "Apolipoprotein L-I is positively associated with hyperglycemia and plasma triglycerides in CAD patients with low HDL". J. Lipid Res. 46 (3): 469–74. doi:10.1194/jlr.M400304-JLR200. PMID 15604524.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pérez-Morga D, Vanhollebeke B, Paturiaux-Hanocq F; et al. (2005). "Apolipoprotein L-I promotes trypanosome lysis by forming pores in lysosomal membranes". Science. 309 (5733): 469–72. doi:10.1126/science.1114566. PMID 16020735.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu T, Qian WJ, Gritsenko MA; et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMID 16335952.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vanhollebeke B, Nielsen MJ, Watanabe Y; et al. (2007). "Distinct roles of haptoglobin-related protein and apolipoprotein L-I in trypanolysis by human serum". Proc. Natl. Acad. Sci. U.S.A. 104 (10): 4118–23. doi:10.1073/pnas.0609902104. PMID 17360487.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)