AREG

Amphiregulin (schwannoma-derived growth factor)
Identifiers
Symbols	AREG ; AR; CRDGF; MGC13647; SDGF
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1252
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Amphiregulin (schwannoma-derived growth factor), also known as AREG, is a human gene.

The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells, and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). This protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells and inhibits the growth of certain aggressive carcinoma cell lines. This encoded protein is associated with a psoriasis-like skin phenotype.

Further reading

• Culouscou JM, Remacle-Bonnet M, Carlton GW; et al. (1993). "Colorectum cell-derived growth factor (CRDGF) is homologous to amphiregulin, a member of the epidermal growth factor family". Growth Factors. 7 (3): 195–205. PMID 1333777.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cook PW, Mattox PA, Keeble WW; et al. (1991). "A heparin sulfate-regulated human keratinocyte autocrine factor is similar or identical to amphiregulin". Mol. Cell. Biol. 11 (5): 2547–57. PMID 2017164.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kimura H, Fischer WH, Schubert D (1990). "Structure, expression and function of a schwannoma-derived growth factor". Nature. 348 (6298): 257–60. doi:10.1038/348257a0. PMID 2234093.CS1 maint: Multiple names: authors list (link)
• Plowman GD, Green JM, McDonald VL; et al. (1990). "The amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity". Mol. Cell. Biol. 10 (5): 1969–81. PMID 2325643.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shoyab M, Plowman GD, McDonald VL; et al. (1989). "Structure and function of human amphiregulin: a member of the epidermal growth factor family". Science. 243 (4894 Pt 1): 1074–6. PMID 2466334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shoyab M, McDonald VL, Bradley JG, Todaro GJ (1988). "Amphiregulin: a bifunctional growth-modulating glycoprotein produced by the phorbol 12-myristate 13-acetate-treated human breast adenocarcinoma cell line MCF-7". Proc. Natl. Acad. Sci. U.S.A. 85 (17): 6528–32. PMID 3413110.CS1 maint: Multiple names: authors list (link)
• Chen CS, Bejcek BE, Kersey JH (1995). "A mapping study of 13 genes on human chromosome bands 4q11-->q25". Cytogenet. Cell Genet. 69 (3–4): 260–5. PMID 7698025.CS1 maint: Multiple names: authors list (link)
• Cook PW, Piepkorn M, Clegg CH; et al. (1997). "Transgenic expression of the human amphiregulin gene induces a psoriasis-like phenotype". J. Clin. Invest. 100 (9): 2286–94. PMID 9410906.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wong L, Deb TB, Thompson SA; et al. (1999). "A differential requirement for the COOH-terminal region of the epidermal growth factor (EGF) receptor in amphiregulin and EGF mitogenic signaling". J. Biol. Chem. 274 (13): 8900–9. PMID 10085134.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Reddy KB, Krueger JS, Kondapaka SB, Diglio CA (1999). "Mitogen-activated protein kinase (MAPK) regulates the expression of progelatinase B (MMP-9) in breast epithelial cells". Int. J. Cancer. 82 (2): 268–73. PMID 10389762.CS1 maint: Multiple names: authors list (link)
• Fernandes AM, Hamburger AW, Gerwin BI (1999). "Production of epidermal growth factor related ligands in tumorigenic and benign human lung epithelial cells". Cancer Lett. 142 (1): 55–63. PMID 10424781.CS1 maint: Multiple names: authors list (link)
• Lee SB, Huang K, Palmer R; et al. (1999). "The Wilms tumor suppressor WT1 encodes a transcriptional activator of amphiregulin". Cell. 98 (5): 663–73. PMID 10490105.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tokumaru S, Higashiyama S, Endo T; et al. (2000). "Ectodomain shedding of epidermal growth factor receptor ligands is required for keratinocyte migration in cutaneous wound healing". J. Cell Biol. 151 (2): 209–20. PMID 11038170.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ebert MP, Hernberg S, Fei G; et al. (2001). "Induction and expression of cyclin D3 in human pancreatic cancer". J. Cancer Res. Clin. Oncol. 127 (7): 449–54. PMID 11469683.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Berquin IM, Dziubinski ML, Nolan GP, Ethier SP (2001). "A functional screen for genes inducing epidermal growth factor autonomy of human mammary epithelial cells confirms the role of amphiregulin". Oncogene. 20 (30): 4019–28. doi:10.1038/sj.onc.1204537. PMID 11494130.CS1 maint: Multiple names: authors list (link)
• Thøgersen VB, Sørensen BS, Poulsen SS; et al. (2001). "A subclass of HER1 ligands are prognostic markers for survival in bladder cancer patients". Cancer Res. 61 (16): 6227–33. PMID 11507076.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wolfgang CD, Essand M, Lee B, Pastan I (2001). "T-cell receptor gamma chain alternate reading frame protein (TARP) expression in prostate cancer cells leads to an increased growth rate and induction of caveolins and amphiregulin". Cancer Res. 61 (22): 8122–6. PMID 11719440.CS1 maint: Multiple names: authors list (link)
• Schiemann U, Konturek J, Assert R; et al. (2002). "mRNA expression of EGF receptor ligands in atrophic gastritis before and after Helicobacter pylori eradication". Med. Sci. Monit. 8 (2): CR53–8. PMID 11859273.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tørring N, Møller-Ernst Jensen K, Lund L; et al. (2002). "Possible autocrine loop of the epidermal growth factor system in patients with benign prostatic hyperplasia treated with finasteride: a placebo-controlled randomized study". BJU Int. 89 (6): 583–90. PMID 11942969.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hurbin A, Dubrez L, Coll JL, Favrot MC (2003). "Inhibition of apoptosis by amphiregulin via an insulin-like growth factor-1 receptor-dependent pathway in non-small cell lung cancer cell lines". J. Biol. Chem. 277 (51): 49127–33. doi:10.1074/jbc.M207584200. PMID 12356750.CS1 maint: Multiple names: authors list (link)