Brefeldin A-inhibited guanine nucleotide-exchange protein 1 is a protein that in humans is encoded by the ARFGEF1 gene .[1] [2] [3]
Function ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. It contains a Sec7 domain, which may be responsible for the guanine-nucleotide exchange activity and also the brefeldin A inhibition.[3]
Interactions ARFGEF1 has been shown to interact with FKBP2 ,[4] ARFGEF2 [5] PRKAR1A .[6]
References
↑ Togawa A, Morinaga N, Ogasawara M, Moss J, Vaughan M (Apr 1999). "Purification and cloning of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors". The Journal of Biological Chemistry . 274 (18): 12308–15. doi :10.1074/jbc.274.18.12308 . PMID 10212200 . ↑ Morinaga N, Tsai SC, Moss J, Vaughan M (Nov 1996). "Isolation of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP ribosylation factor (ARF) 1 and ARF3 that contains a Sec7-like domain" . Proceedings of the National Academy of Sciences of the United States of America . 93 (23): 12856–60. doi :10.1073/pnas.93.23.12856 . PMC 24010 PMID 8917509 . ↑ 3.0 3.1 "Entrez Gene: ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)" .↑ Padilla PI, Chang MJ, Pacheco-Rodriguez G, Adamik R, Moss J, Vaughan M (Mar 2003). "Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): effects of FK506" . Proceedings of the National Academy of Sciences of the United States of America . 100 (5): 2322–7. doi :10.1073/pnas.2628047100 . PMC 151339 PMID 12606707 . ↑ Yamaji R, Adamik R, Takeda K, Togawa A, Pacheco-Rodriguez G, Ferrans VJ, Moss J, Vaughan M (Mar 2000). "Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex" . Proceedings of the National Academy of Sciences of the United States of America . 97 (6): 2567–72. doi :10.1073/pnas.97.6.2567 . PMC 15969 PMID 10716990 . ↑ Li H, Adamik R, Pacheco-Rodriguez G, Moss J, Vaughan M (Feb 2003). "Protein kinase A-anchoring (AKAP) domains in brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2)" . Proceedings of the National Academy of Sciences of the United States of America . 100 (4): 1627–32. doi :10.1073/pnas.0337678100 . PMC 149883 PMID 12571360 .
External links Further reading
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research . 6 (9): 791–806. doi :10.1101/gr.6.9.791 . PMID 8889548 . Mansour SJ, Skaug J, Zhao XH, Giordano J, Scherer SW, Melançon P (Jul 1999). "p200 ARF-GEP1: a Golgi-localized guanine nucleotide exchange protein whose Sec7 domain is targeted by the drug brefeldin A" . Proceedings of the National Academy of Sciences of the United States of America . 96 (14): 7968–73. doi :10.1073/pnas.96.14.7968 . PMC 22171 PMID 10393931 . Yamaji R, Adamik R, Takeda K, Togawa A, Pacheco-Rodriguez G, Ferrans VJ, Moss J, Vaughan M (Mar 2000). "Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex" . Proceedings of the National Academy of Sciences of the United States of America . 97 (6): 2567–72. doi :10.1073/pnas.97.6.2567 . PMC 15969 PMID 10716990 . Kamei Y, Takeda Y, Teramoto K, Tsutsumi O, Taketani Y, Watanabe K (Oct 2000). "Human NB-2 of the contactin subgroup molecules: chromosomal localization of the gene (CNTN5) and distinct expression pattern from other subgroup members". Genomics . 69 (1): 113–9. doi :10.1006/geno.2000.6310 . PMID 11013081 . Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, et al. (Jan 2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nature Genetics . 36 (1): 40–5. doi :10.1038/ng1285 . PMID 14702039 . Padilla PI, Pacheco-Rodriguez G, Moss J, Vaughan M (Mar 2004). "Nuclear localization and molecular partners of BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors" . Proceedings of the National Academy of Sciences of the United States of America . 101 (9): 2752–7. doi :10.1073/pnas.0307345101 . PMC 365693 PMID 14973189 . Saeki N, Tokuo H, Ikebe M (Mar 2005). "BIG1 is a binding partner of myosin IXb and regulates its Rho-GTPase activating protein activity". The Journal of Biological Chemistry . 280 (11): 10128–34. doi :10.1074/jbc.M413415200 . PMID 15644318 . Citterio C, Jones HD, Pacheco-Rodriguez G, Islam A, Moss J, Vaughan M (Feb 2006). "Effect of protein kinase A on accumulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) in HepG2 cell nuclei" . Proceedings of the National Academy of Sciences of the United States of America . 103 (8): 2683–8. doi :10.1073/pnas.0510571103 . PMC 1413798 PMID 16467138 . Belov GA, Altan-Bonnet N, Kovtunovych G, Jackson CL, Lippincott-Schwartz J, Ehrenfeld E (Jan 2007). "Hijacking components of the cellular secretory pathway for replication of poliovirus RNA" . Journal of Virology . 81 (2): 558–67. doi :10.1128/JVI.01820-06 . PMC 1797456 PMID 17079330 . Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell . 127 (3): 635–48. doi :10.1016/j.cell.2006.09.026 . PMID 17081983 . Shen X, Hong MS, Moss J, Vaughan M (Jan 2007). "BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein, is required for correct glycosylation and function of integrin beta1" . Proceedings of the National Academy of Sciences of the United States of America . 104 (4): 1230–5. doi :10.1073/pnas.0610535104 . PMC 1783117 PMID 17227842 . Kuroda F, Moss J, Vaughan M (Feb 2007). "Regulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) and BIG2 activity via PKA and protein phosphatase 1gamma" . Proceedings of the National Academy of Sciences of the United States of America . 104 (9): 3201–6. doi :10.1073/pnas.0611696104 . PMC 1805514 PMID 17360629 .
