Cysteine protease ATG4A is an enzyme that in humans is encoded by the ATG4Agene.[1][2][3]
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodelling during differentiation, metamorphosis, non-apoptoticcell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteineproteases. Transcript variants that encode distinct isoforms have been identified.[3]
References
↑Marino G, Uria JA, Puente XS, Quesada V, Bordallo J, Lopez-Otin C (Feb 2003). "Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy". J Biol Chem. 278 (6): 3671–8. doi:10.1074/jbc.M208247200. PMID12446702.
↑Scherz-Shouval R, Sagiv Y, Shorer H, Elazar Z (Apr 2003). "The COOH terminus of GATE-16, an intra-Golgi transport modulator, is cleaved by the human cysteine protease HsApg4A". J Biol Chem. 278 (16): 14053–8. doi:10.1074/jbc.M212108200. PMID12473658.
Kabeya Y, Mizushima N, Yamamoto A, et al. (2005). "LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation". J. Cell Sci. 117 (Pt 13): 2805–12. doi:10.1242/jcs.01131. PMID15169837.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.
