ATP-dependent DNA helicase 2 subunit 2

X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining; Ku autoantigen, 80kDa)
PDB rendering based on 1jeq.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1jeq​, 1jey​, 1q2z​, 1rw2​
Identifiers
Symbols	XRCC5 ; FLJ39089; KARP-1; KARP1; KU80; KUB2; Ku86; NFIV
External IDs	Template:OMIM5 Template:MGI HomoloGene: 40681
EC number	3.6.1. EC 3.6.1.
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining; Ku autoantigen, 80kDa), also known as XRCC5, is a human gene.

The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.

Further reading

• Koike M (2003). "Dimerization, translocation and localization of Ku70 and Ku80 proteins". J. Radiat. Res. 43 (3): 223–36. PMID 12518983.
• Chen DJ, Park MS, Campbell E; et al. (1992). "Assignment of a human DNA double-strand break repair gene (XRCC5) to chromosome 2". Genomics. 13 (4): 1088–94. PMID 1505945.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wedrychowski A, Henzel W, Huston L; et al. (1992). "Identification of proteins binding to interferon-inducible transcriptional enhancers in hematopoietic cells". J. Biol. Chem. 267 (7): 4533–40. PMID 1537839.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jeggo PA, Hafezparast M, Thompson AF; et al. (1992). "Localization of a DNA repair gene (XRCC5) involved in double-strand-break rejoining to human chromosome 2". Proc. Natl. Acad. Sci. U.S.A. 89 (14): 6423–7. PMID 1631138.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Knuth MW, Gunderson SI, Thompson NE; et al. (1990). "Purification and characterization of proximal sequence element-binding protein 1, a transcription activating protein related to Ku and TREF that binds the proximal sequence element of the human U1 promoter". J. Biol. Chem. 265 (29): 17911–20. PMID 2211668.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Stuiver MH, Coenjaerts FE, van der Vliet PC (1990). "The autoantigen Ku is indistinguishable from NF IV, a protein forming multimeric protein-DNA complexes". J. Exp. Med. 172 (4): 1049–54. PMID 2212941.CS1 maint: Multiple names: authors list (link)
• Mimori T, Ohosone Y, Hama N; et al. (1990). "Isolation and characterization of cDNA encoding the 80-kDa subunit protein of the human autoantigen Ku (p70/p80) recognized by autoantibodies from patients with scleroderma-polymyositis overlap syndrome". Proc. Natl. Acad. Sci. U.S.A. 87 (5): 1777–81. PMID 2308937.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yaneva M, Wen J, Ayala A, Cook R (1989). "cDNA-derived amino acid sequence of the 86-kDa subunit of the Ku antigen". J. Biol. Chem. 264 (23): 13407–11. PMID 2760028.CS1 maint: Multiple names: authors list (link)
• Genersch E, Eckerskorn C, Lottspeich F; et al. (1995). "Purification of the sequence-specific transcription factor CTCBF, involved in the control of human collagen IV genes: subunits with homology to Ku antigen". EMBO J. 14 (4): 791–800. PMID 7882982.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tuteja N, Tuteja R, Ochem A; et al. (1994). "Human DNA helicase II: a novel DNA unwinding enzyme identified as the Ku autoantigen". EMBO J. 13 (20): 4991–5001. PMID 7957065.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Le Romancer M, Reyl-Desmars F, Cherifi Y; et al. (1994). "The 86-kDa subunit of autoantigen Ku is a somatostatin receptor regulating protein phosphatase-2A activity". J. Biol. Chem. 269 (26): 17464–8. PMID 8021251.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cao QP, Pitt S, Leszyk J, Baril EF (1994). "DNA-dependent ATPase from HeLa cells is related to human Ku autoantigen". Biochemistry. 33 (28): 8548–57. PMID 8031790.CS1 maint: Multiple names: authors list (link)
• Taccioli GE, Gottlieb TM, Blunt T; et al. (1994). "Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination". Science. 265 (5177): 1442–5. PMID 8073286.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen DJ, Marrone BL, Nguyen T; et al. (1994). "Regional assignment of a human DNA repair gene (XRCC5) to 2q35 by X-ray hybrid mapping". Genomics. 21 (2): 423–7. doi:10.1006/geno.1994.1287. PMID 8088837.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Kaczmarski W, Khan SA (1993). "Lupus autoantigen Ku protein binds HIV-1 TAR RNA in vitro". Biochem. Biophys. Res. Commun. 196 (2): 935–42. doi:10.1006/bbrc.1993.2339. PMID 8240370.
• Blunt T, Taccioli GE, Priestley A; et al. (1996). "A YAC contig encompassing the XRCC5 (Ku80) DNA repair gene and complementation of defective cells by YAC protoplast fusion". Genomics. 30 (2): 320–8. PMID 8586433.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Warriar N, Pagé N, Govindan MV (1996). "Expression of human glucocorticoid receptor gene and interaction of nuclear proteins with the transcriptional control element". J. Biol. Chem. 271 (31): 18662–71. PMID 8702520.CS1 maint: Multiple names: authors list (link)
• Myung K, He DM, Lee SE, Hendrickson EA (1997). "KARP-1: a novel leucine zipper protein expressed from the Ku86 autoantigen locus is implicated in the control of DNA-dependent protein kinase activity". EMBO J. 16 (11): 3172–84. doi:10.1093/emboj/16.11.3172. PMID 9214634.CS1 maint: Multiple names: authors list (link)
• Jin S, Kharbanda S, Mayer B; et al. (1997). "Binding of Ku and c-Abl at the kinase homology region of DNA-dependent protein kinase catalytic subunit". J. Biol. Chem. 272 (40): 24763–6. PMID 9312071.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)