Acinic cell carcinoma classification
|
Acinic cell carcinoma Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case studies |
|
Acinic cell carcinoma classification On the Web |
|
American Roentgen Ray Society Images of Acinic cell carcinoma classification |
|
Risk calculators and risk factors for Acinic cell carcinoma classification |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ramyar Ghandriz MD[2]
Overview
Based on the 8th edition of American Joint Committee on Cancer(AJCC) and Union for International Cancer Control (UICC)the staging of salivary gland neoplasms are staged by TNM system.This means acinic cell carcinoma is staged based on tumor, node, and metastasis similar to squamous cell carcinoma.
Classification
Based on the 8th edition of American Joint Committee on Cancer(AJCC) and Union for International Cancer Control (UICC) the staging of salivary gland neoplasms are staged by TNM system. This means acinic cell carcinoma is staged based on tumor, node, and metastasis similar to squamous cell carcinoma.[1]
T: Primary Tumor
| T | Description |
|---|---|
| TX | Primary tumor cannot be assessed |
| T0 | No evidence of primary tumor |
| Ta | Papillary noninvasive carcinoma |
| Tis | Carcinoma in situ |
| T1 | Tumor invades subepithelial connective tissue |
| T2 | Tumor invades the muscularis |
| T3 | (For renal pelvis only) Tumor invades beyond muscularis into peripelvic fat or the renal parenchyma T3. (For ureter only) Tumor invades beyond muscularis into periureteric fat |
| T4 | Tumor invades adjacent organs, or through the kidney into the perinephric fat |
N:Regional Lymph Nodes
| N | Description |
|---|---|
| NX | Regional lymph nodes cannot be assessed |
| N0 | No regional lymph node metastasis |
| N1 | Metastasis in a single lymph node, ≤2 cm in greatest dimension |
| N2 | Metastasis in a single lymph node, >2 cm but not >5 cm in greatest dimension; or multiple lymph nodes, none >5 cm in greatest dimension |
| N3 | Metastasis in a lymph node, >5 cm in greatest dimension |
M: Distant Metastasis
| T | Description |
| M0 | There is no evidence of distant metastasis |
| M1 | There is evidence of distant metastasis |
TNM Classification
| Stage | T | N | M |
| Stage 0a | Ta | N0 | M0 |
| Stage 0is | Tis | N0 | M0 |
| Stage I | T1 | N0 | M0 |
| Stage II | T2 | N0 | M0 |
| Stage III | T3 | N0 | M0 |
| Stage IV | T4 | N0 | M0 |
| Any T | N1 | M0 | |
| Any T | N2 | M0 | |
| Any T | N3 | M0 | |
| Any T | Any N | M1 |
* Acinic cell carcinoma is classified due its different histiological featurs as bellow:[2]
| Acinic-intercalated ductal carcinoma family | |
|---|---|
| Solid acinic cell carcinoma | Serous cells adenocarsinoma |
| Cacinomas of various proportions | Various proportion of acinic and intercalated duct-like cells |
| Carcinomas intercalated duct-like cells | Microcytic, papillary, follicular, cystic and mixed architectural arrangments |
| s-100 protein (-) | Considered immunohistochemisty for DOGI |
| s-100 protein (+)/MASC | Consider immunohistochemistry for mammaglobin, ETV6 FISH |
References
- ↑ Son, Eugene; Panwar, Aru; Mosher, Charles H.; Lydiatt, Daniel (2018). "Cancers of the Major Salivary Gland". Journal of Oncology Practice. 14 (2): 99–108. doi:10.1200/JOP.2017.026856. ISSN 1554-7477.
- ↑ Chiosea, Simion I.; Griffith, Christopher; Assaad, Adel; Seethala, Raja R. (2012). "The Profile of Acinic Cell Carcinoma After Recognition of Mammary Analog Secretory Carcinoma". The American Journal of Surgical Pathology. 36 (3): 343–350. doi:10.1097/PAS.0b013e318242a5b0. ISSN 0147-5185.