Acute disseminated encephalomyelitis other diagnostic studies
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Differentiating Acute disseminated encephalomyelitis from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sujaya Chattopadhyay, M.D.[2]
Overview
Many experts discourage diagnostic biopsies in the absence of structured histopathological guidelines. Nevertheless, typical lesions of ADEM may be identified by histopathology anywhere in the white matter of brain and spinal cord.
Other Diagnostic Studies
Guided brain biopsy[1]
Many experts discourage diagnostic biopsies in absence of structured histopathological guidelines. Nevertheless, typical lesions of ADEM may be identified by histopathology anywhere in the white matter of brain and spinal cord.
- Perivascular infiltration with macrophages and T cells with polymorphs in very early stages and no confluent demyelination
- Astrocyte hyperplasia and gliosis in advanced stages
References
- ↑ Hoche F, Pfeifenbring S, Vlaho S, Qirshi M, Theis M, Schneider W; et al. (2011). "Rare brain biopsy findings in a first ADEM-like event of pediatric MS: histopathologic, neuroradiologic and clinical features". J Neural Transm (Vienna). 118 (9): 1311–7. doi:10.1007/s00702-011-0609-6. PMC 3291843. PMID 21547392.