Afterhyperpolarization

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Afterhyperpolarization describes the part of an inactivation phase of an action potential where the membrane falls below the normal resting potential. Both medium and slow afterhyperpolarization currents (mI_AHP and sI_AHP, respectively) can be demonstrated in neurones . The SK Channel is the major mediator of AHP currents, although other candidate mediators have been suggested.