Aggressive NK-cell leukemia history and symptoms
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [3]
History and Symptoms
Patients usually present with constitutional symptoms (malaise, weight loss, fatigue), and hepatosplenomegaly is commonly found on physical exam. Lymphadenopathy is also found to a lesser extent. Due to the aggressive nature of the disease, patients may initially present at a more advanced stage, with coagulopathies, hemophagocytic syndrome, and multi-organ failure.[1][2]
References
- ↑ [1] Kobayashi Y, Uehara S, Inamori K, Shirato R, Ozawa K, Sklar J, Asano S. "Hemophagocytosis as a para-neoplastic syndrome in NK cell leukemia." Int J Hematol. 1996 Aug;64(2):135-42. PMID: 8854571
- ↑ [2] Okuda T, Sakamoto S, Deguchi T, Misawa S, Kashima K, Yoshihara T, Ikushima S, Hibi S, Imashuku S. "Hemophagocytic syndrome associated with aggressive natural killer cell leukemia." Am J Hematol. 1991 Dec;38(4):321-3. PMID: 1746541