Aldolase-B
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| aldolase B, fructose-bisphosphate | |
|---|---|
| Identifiers | |
| Symbol | ALDOB |
| Entrez | 229 |
| HUGO | 417 |
| OMIM | 229600 |
| RefSeq | NM_000035 |
| UniProt | P05062 |
| Other data | |
| EC number | 4.1.2.13 |
| Locus | Chr. 9 q21.3-22.2 |
Aldolase B is an isoenzyme of fructose 1,6-bisphosphate aldolase (aldolase A), which is also capable of cleaving fructose 1-phosphate to form glyceraldehyde and dihydroxyacetone phosphate (DHAP). The reaction is reversible. Also known as Aldolase (Class II), it is found in the liver and kidney.
Pathology
Defects of aldolase B cause fructose 1-phosphate to accumulate in tissues which contain fructokinase, a condition known as hereditary fructose intolerance.
External links
- Aldolase+B at the US National Library of Medicine Medical Subject Headings (MeSH)
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