AlkB homolog 5, RNA demethylase

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

AlkB homolog 5, RNA demethylase is a protein that in humans is encoded by the ALKBH5 gene.

Further reading

• Thalhammer A, Bencokova Z, Poole R, Loenarz C, Adam J, O'Flaherty L, Schödel J, Mole D, Giaslakiotis K, Schofield CJ, Hammond EM, Ratcliffe PJ, Pollard PJ (2011). "Human AlkB homologue 5 is a nuclear 2-oxoglutarate dependent oxygenase and a direct target of hypoxia-inducible factor 1α (HIF-1α)". PLoS ONE. 6 (1): e16210. doi:10.1371/journal.pone.0016210. PMC 3021549. PMID 21264265.
• Zheng G, Dahl JA, Niu Y, Fedorcsak P, Huang CM, Li CJ, Vågbø CB, Shi Y, Wang WL, Song SH, Lu Z, Bosmans RP, Dai Q, Hao YJ, Yang X, Zhao WM, Tong WM, Wang XJ, Bogdan F, Furu K, Fu Y, Jia G, Zhao X, Liu J, Krokan HE, Klungland A, Yang YG, He C (2013). "ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility". Mol. Cell. 49 (1): 18–29. doi:10.1016/j.molcel.2012.10.015. PMC 3646334. PMID 23177736.
• Aik W, Scotti JS, Choi H, Gong L, Demetriades M, Schofield CJ, McDonough MA (2014). "Structure of human RNA N⁶-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation". Nucleic Acids Res. 42 (7): 4741–54. doi:10.1093/nar/gku085. PMC 3985658. PMID 24489119.
• Feng C, Liu Y, Wang G, Deng Z, Zhang Q, Wu W, Tong Y, Cheng C, Chen Z (2014). "Crystal structures of the human RNA demethylase Alkbh5 reveal basis for substrate recognition". J. Biol. Chem. 289 (17): 11571–83. doi:10.1074/jbc.M113.546168. PMC 4002068. PMID 24616105.
• Xu C, Liu K, Tempel W, Demetriades M, Aik W, Schofield CJ, Min J (2014). "Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation". J. Biol. Chem. 289 (25): 17299–311. doi:10.1074/jbc.M114.550350. PMC 4067165. PMID 24778178.
• Du T, Rao S, Wu L, Ye N, Liu Z, Hu H, Xiu J, Shen Y, Xu Q (2015). "An association study of the m6A genes with major depressive disorder in Chinese Han population". J Affect Disord. 183: 279–86. doi:10.1016/j.jad.2015.05.025. PMID 26047305.
• Zhang C, Samanta D, Lu H, Bullen JW, Zhang H, Chen I, He X, Semenza GL (2016). "Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m⁶A-demethylation of NANOG mRNA". Proc. Natl. Acad. Sci. U.S.A. 113 (14): E2047–56. doi:10.1073/pnas.1602883113. PMC 4833258. PMID 27001847.