Allylestrenol

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Allylestrenol
Clinical data
Synonyms	17α-Allylestr-4-en-17β-ol
Pregnancy; category	Used in threatened miscarriage and RPL;
ATC code	G03DC01 (WHO) ;
Identifiers
	IUPAC name (17β)-17-(prop-2-en-1-yl)estr-4-en-17-ol;
CAS Number	432-60-0 ;
PubChem CID	235905;
DrugBank	DB01431 ;
ChemSpider	205855 ;
UNII	I47VB5DZ8O;
KEGG	D01374 ;
ChEMBL	ChEMBL1445549 ;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C21H32O
Molar mass	300.48 g/mol
3D model (JSmol)	Interactive image;
	SMILES O[C@]2(CC[C@H]1[C@H]4[C@H](CC[C@@]12C)[C@@H]3\C(=C/CCC3)CC4)C\C=C;
	InChI InChI=1S/C21H32O/c1-3-12-21(22)14-11-19-18-9-8-15-6-4-5-7-16(15)17(18)10-13-20(19,21)2/h3,6,16-19,22H,1,4-5,7-14H2,2H3/t16-,17+,18+,19-,20-,21-/m0/s1 ; Key:ATXHVCQZZJYMCF-XUDSTZEESA-N ;
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Allylestrenol (BAN/INN), also known as allyloestrenol and allyl estrenol, is a synthetic progestogen used to prevent threatened miscarriage, recurrent pregnancy loss and premature labor.^[1]^[2] In men, it has also been studied as a treatment for benign prostatic hyperplasia, with encouraging results.^[3]^[4]

Allylestrenol is sold under several trade names, including Gestin, Turinal,Gestrenol, Gestanin, Gestanol or Gestanon, Maintaine, Orageston, and Profar. It is currently not marketed in the United States, United Kingdom, or Canada, but as of 2011^[update], is extensively used in Bangladesh,Japan, Russia, India, and much of Southeast Asia.^[1]

References

↑ ^1.0 ^1.1 Sweetman, Sean C., ed. (2009). "Sex hormones and their modulators". Martindale: the complete drug reference (36th ed.). London: Pharmaceutical Press. p. 2082. ISBN 978-0-85369-840-1.
↑ Cortés-Prieto J, Bosch AO, Rocha JA (1980). "Allylestrenol: three years of experience with Gestanon in threatened abortion and premature labor". Clinical Therapeutics. 3 (3): 200–8. PMID 7459930.
↑ Fukuoka H, Ishibashi Y, Shiba T, Tuchiya F, Sakanishi S (July 1993). "[Clinical study of allylestrenol (Perselin) on patients with prostatic hypertrophy]". Hinyokika Kiyo. Acta Urologica Japonica (in Japanese). 39 (7): 679–83. PMID 7689782.
↑ Noguchi K, Takeda M, Hosaka M, Kubota Y (May 2002). "[Clinical effects of allylestrenol on patients with benign prostatic hyperplasia (BPH) evaluated with criteria for treatment efficacy in BPH]". Hinyokika Kiyo. Acta Urologica Japonica (in Japanese). 48 (5): 269–73. PMID 12094708.

[Martindale-1] 1.0 ^1.1 Sweetman, Sean C., ed. (2009). "Sex hormones and their modulators". Martindale: the complete drug reference (36th ed.). London: Pharmaceutical Press. p. 2082. ISBN 978-0-85369-840-1.

[2] Cortés-Prieto J, Bosch AO, Rocha JA (1980). "Allylestrenol: three years of experience with Gestanon in threatened abortion and premature labor". Clinical Therapeutics. 3 (3): 200–8. PMID 7459930.

[3] Fukuoka H, Ishibashi Y, Shiba T, Tuchiya F, Sakanishi S (July 1993). "[Clinical study of allylestrenol (Perselin) on patients with prostatic hypertrophy]". Hinyokika Kiyo. Acta Urologica Japonica (in Japanese). 39 (7): 679–83. PMID 7689782.

[4] Noguchi K, Takeda M, Hosaka M, Kubota Y (May 2002). "[Clinical effects of allylestrenol on patients with benign prostatic hyperplasia (BPH) evaluated with criteria for treatment efficacy in BPH]". Hinyokika Kiyo. Acta Urologica Japonica (in Japanese). 48 (5): 269–73. PMID 12094708.

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[2]

[3]

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Clinical data

Synonyms	17α-Allylestr-4-en-17β-ol
Pregnancy category	Used in threatened miscarriage and RPL
ATC code	G03DC01 (WHO)
Identifiers
IUPAC name (17β)-17-(prop-2-en-1-yl)estr-4-en-17-ol
CAS Number	432-60-0^Y
PubChem CID	235905
DrugBank	DB01431^Y
ChemSpider	205855^Y
UNII	I47VB5DZ8O
KEGG	D01374^Y
ChEMBL	ChEMBL1445549^N
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₂₁H₃₂O
Molar mass	300.48 g/mol
3D model (JSmol)	Interactive image
SMILES O[C@]2(CC[C@H]1[C@H]4[C@H](CC[C@@]12C)[C@@H]3\C(=C/CCC3)CC4)C\C=C
InChI InChI=1S/C21H32O/c1-3-12-21(22)14-11-19-18-9-8-15-6-4-5-7-16(15)17(18)10-13-20(19,21)2/h3,6,16-19,22H,1,4-5,7-14H2,2H3/t16-,17+,18+,19-,20-,21-/m0/s1^Y Key:ATXHVCQZZJYMCF-XUDSTZEESA-N^Y
^NY (what is this?) (verify)

Allylestrenol

Overview

References

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