Amoxicillin-clavulanate potassium indications and usage
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamed Moubarak, M.D. [2]
Indications and Usage
To reduce the development of drug‑resistant bacteria and maintain the effectiveness of AUGMENTIN (amoxicillin/clavulanate potassium) and other antibacterial drugs, AUGMENTIN should be used only to treat infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
AUGMENTIN® is a combination penicillin-class antibacterial and beta-lactamase inhibitor indicated in the treatment of infections due to susceptible isolates of the designated bacteria in the conditions listed below*:
- Lower Respiratory Tract Infections
caused by beta‑lactamase–producing isolates of Haemophilus influenzae and Moraxella catarrhalis.
- Acute Bacterial Otitis Media
caused by beta‑lactamase–producing isolates of H. influenzae and M. catarrhalis.
- Sinusitis
caused by beta‑lactamase–producing isolates of H. influenzae and M. catarrhalis.
- Skin and Skin Structure Infections
caused by beta‑lactamase–producing isolates of Staphylococcus aureus, Escherichia coli, and Klebsiella species.
- Urinary Tract Infections
caused by beta‑lactamase–producing isolates of E. coli, Klebsiella species, and Enterobacter species.
- Limitations of Use
When susceptibility test results show susceptibility to amoxicillin, indicating no beta-lactamase production, AUGMENTIN should not be used.[1]
References
Adapted from the FDA Package Insert.