Anaplastic large cell lymphoma diagnostic criteria
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Diagnostic Criteria
To make this diagnosis under its present system of classification, the WHO:
Requires
- The presence of "hallmark" cells
- Immunopositivity for CD30
Acknowledges as typical, but does not require
- Immunopositivity for ALK (anaplastic lymphoma kinase) protein
Specifically excludes
- Primary cutaneous T-cell lymphomas
- Other specific types of anaplastic lymphoma (particularly those of B-cell lineage) with CD30 positivity