Antiphospholipid syndrome laboratory findings
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Feham Tariq, MD [2]
Overview
Antiphospholipid syndrome (APS) is tested for in the laboratory by both liquid phase coagulation assays (lupus anticoagulant) and solid phase ELISA assays (anti-cardiolipin antibodies). Antibodies found in the plasma os patients with APS are lupus anticoagulant, anticariolipin (aCL), beta-2 glycoprotein I, anti-phosphatidylserine antibodies, anti-prothrombin antibodies. The criteria for testing antiphospholipid antibodies in the plasma is postivity on 2 or more occasion at least 12 weeks apart.
Laboratory Findings
The following antibodies are found in the plasma of patients with APS:[1][2][3][4]
| Laboratory Findings (Antibodies) |
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Criteria for testing Antiphospholipid antibodies:
- Presence of lupus anticoagulant (LA) in plasma on two or more occasions minimum 12 weeks apart.
- Presence of moderate to high levels of anticardiolipin (aCL) (IgG or IgM) in serum or plasma on two or more occasions minimum 12 weeks apart.
- Presence of moderate to high levels of anti–beta-2 glycoprotein I antibodies (IgG or IgM) in plasma or serum on two or more occasions minimum 12 weeks apart.
| Common Laboratory findings |
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References
- ↑ Giannakopoulos B, Passam F, Ioannou Y, Krilis SA (2009). "How we diagnose the antiphospholipid syndrome". Blood. 113 (5): 985–94. doi:10.1182/blood-2007-12-129627. PMID 18755986.
- ↑ Galli M (2008). "Clinical utility of laboratory tests used to identify antiphospholipid antibodies and to diagnose the antiphospholipid syndrome". Semin Thromb Hemost. 34 (4): 329–34. doi:10.1055/s-0028-1085474. PMID 18814065.
- ↑ Li R, Daguzan M, Vandermijnsbrugge F, Gyling M, Cantinieaux B (2014). "Both IgG and IgM anti-beta2 glycoprotein I antibodies assays are clinically useful to the antiphospholipid syndrome diagnosis". Acta Clin Belg. 69 (6): 433–8. doi:10.1179/2295333714Y.0000000060. PMID 25103595.
- ↑ Musial J, Swadzba J, Motyl A, Iwaniec T (2003). "Clinical significance of antiphospholipid protein antibodies. Receiver operating characteristics plot analysis". J Rheumatol. 30 (4): 723–30. PMID 12672190.