BCL2A1

BCL2-related protein A1
Identifiers
Symbols	BCL2A1 ; ACC-1; ACC-2; BCL2L5; BFL1; GRS; HBPA1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2988
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

BCL2-related protein A1, also known as BCL2A1, is a human gene.

This gene encodes a member of the bcl2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and has been shown to be up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival.

Further reading

• Choi SS, Park IC, Yun JW; et al. (1995). "A novel Bcl-2 related gene, Bfl-1, is overexpressed in stomach cancer and preferentially expressed in bone marrow". Oncogene. 11 (9): 1693–8. PMID 7478596.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lin EY, Orlofsky A, Berger MS, Prystowsky MB (1993). "Characterization of A1, a novel hemopoietic-specific early-response gene with sequence similarity to bcl-2". J. Immunol. 151 (4): 1979–88. PMID 8345191.CS1 maint: Multiple names: authors list (link)
• Savitsky K, Sfez S, Tagle DA; et al. (1996). "The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species". Hum. Mol. Genet. 4 (11): 2025–32. PMID 8589678.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Karsan A, Yee E, Kaushansky K, Harlan JM (1996). "Cloning of human Bcl-2 homologue: inflammatory cytokines induce human A1 in cultured endothelial cells". Blood. 87 (8): 3089–96. PMID 8605321.CS1 maint: Multiple names: authors list (link)
• Karsan A, Yee E, Harlan JM (1996). "Endothelial cell death induced by tumor necrosis factor-alpha is inhibited by the Bcl-2 family member, A1". J. Biol. Chem. 271 (44): 27201–4. PMID 8910286.CS1 maint: Multiple names: authors list (link)
• Carrió R, López-Hoyos M, Jimeno J; et al. (1997). "A1 demonstrates restricted tissue distribution during embryonic development and functions to protect against cell death". Am. J. Pathol. 149 (6): 2133–42. PMID 8952545.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kenny JJ, Knobloch TJ, Augustus M; et al. (1997). "GRS, a novel member of the Bcl-2 gene family, is highly expressed in multiple cancer cell lines and in normal leukocytes". Oncogene. 14 (8): 997–1001. doi:10.1038/sj.onc.1200898. PMID 9050999.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Choi SS, Park SH, Kim UJ, Shin HS (1997). "Bfl-1, a Bcl-2-related gene, is the human homolog of the murine A1, and maps to chromosome 15q24.3". Mamm. Genome. 8 (10): 781–2. PMID 9321477.CS1 maint: Multiple names: authors list (link)
• Hsu SY, Kaipia A, McGee E; et al. (1997). "Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members". Proc. Natl. Acad. Sci. U.S.A. 94 (23): 12401–6. PMID 9356461.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Takemoto Y, Furuta M, Sato M; et al. (1998). "Growth factor receptor-bound protein 2 (Grb2) association with hemopoietic specific protein 1: linkage between Lck and Grb2". J. Immunol. 161 (2): 625–30. PMID 9670936.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zong WX, Edelstein LC, Chen C; et al. (1999). "The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis". Genes Dev. 13 (4): 382–7. PMID 10049353.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Holmgreen SP, Huang DC, Adams JM, Cory S (1999). "Survival activity of Bcl-2 homologs Bcl-w and A1 only partially correlates with their ability to bind pro-apoptotic family members". Cell Death Differ. 6 (6): 525–32. doi:10.1038/sj.cdd.4400519. PMID 10381646.CS1 maint: Multiple names: authors list (link)
• Lee HH, Dadgostar H, Cheng Q; et al. (1999). "NF-kappaB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes". Proc. Natl. Acad. Sci. U.S.A. 96 (16): 9136–41. PMID 10430908.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang CY, Guttridge DC, Mayo MW, Baldwin AS (1999). "NF-kappaB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis". Mol. Cell. Biol. 19 (9): 5923–9. PMID 10454539.CS1 maint: Multiple names: authors list (link)
• Tomayko MM, Punt JA, Bolcavage JM; et al. (1999). "Expression of the Bcl-2 family member A1 is developmentally regulated in T cells". Int. Immunol. 11 (11): 1753–61. PMID 10545479.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang H, Cowan-Jacob SW, Simonen M; et al. (2000). "Structural basis of BFL-1 for its interaction with BAX and its anti-apoptotic action in mammalian and yeast cells". J. Biol. Chem. 275 (15): 11092–9. PMID 10753914.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Duriez PJ, Wong F, Dorovini-Zis K; et al. (2000). "A1 functions at the mitochondria to delay endothelial apoptosis in response to tumor necrosis factor". J. Biol. Chem. 275 (24): 18099–107. doi:10.1074/jbc.M908925199. PMID 10849436.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Harrington JJ, Sherf B, Rundlett S; et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bae J, Hsu SY, Leo CP; et al. (2001). "Underphosphorylated BAD interacts with diverse antiapoptotic Bcl-2 family proteins to regulate apoptosis". Apoptosis. 6 (5): 319–30. PMID 11483855.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Akari H, Bour S, Kao S; et al. (2001). "The human immunodeficiency virus type 1 accessory protein Vpu induces apoptosis by suppressing the nuclear factor kappaB-dependent expression of antiapoptotic factors". J. Exp. Med. 194 (9): 1299–311. PMID 11696595.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)