BLK (gene)

B lymphoid tyrosine kinase
Identifiers
Symbols	BLK ; MGC10442
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1297
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

B lymphoid tyrosine kinase, also known as BLK, is a human gene.

Further reading

• Dymecki SM, Niederhuber JE, Desiderio SV (1990). "Specific expression of a tyrosine kinase gene, blk, in B lymphoid cells". Science. 247 (4940): 332–6. PMID 2404338.CS1 maint: Multiple names: authors list (link)
• Lin YH, Shin EJ, Campbell MJ, Niederhuber JE (1995). "Transcription of the blk gene in human B lymphocytes is controlled by two promoters". J. Biol. Chem. 270 (43): 25968–75. PMID 7592787.CS1 maint: Multiple names: authors list (link)
• Saouaf SJ, Kut SA, Fargnoli J; et al. (1995). "Reconstitution of the B cell antigen receptor signaling components in COS cells". J. Biol. Chem. 270 (45): 27072–8. PMID 7592958.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Islam KB, Rabbani H, Larsson C; et al. (1995). "Molecular cloning, characterization, and chromosomal localization of a human lymphoid tyrosine kinase related to murine Blk". J. Immunol. 154 (3): 1265–72. PMID 7822795.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Drebin JA, Hartzell SW, Griffin C; et al. (1995). "Molecular cloning and chromosomal localization of the human homologue of a B-lymphocyte specific protein tyrosine kinase (blk)". Oncogene. 10 (3): 477–86. PMID 7845672.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Donovan JA, Wange RL, Langdon WY, Samelson LE (1994). "The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor". J. Biol. Chem. 269 (37): 22921–4. PMID 8083187.CS1 maint: Multiple names: authors list (link)
• Pleiman CM, Clark MR, Gauen LK; et al. (1993). "Mapping of sites on the Src family protein tyrosine kinases p55blk, p59fyn, and p56lyn which interact with the effector molecules phospholipase C-gamma 2, microtubule-associated protein kinase, GTPase-activating protein, and phosphatidylinositol 3-kinase". Mol. Cell. Biol. 13 (9): 5877–87. PMID 8395016.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Malek SN, Yang CH, Earnshaw WC; et al. (1996). "p150TSP, a conserved nuclear phosphoprotein that contains multiple tetratricopeptide repeats and binds specifically to SH2 domains". J. Biol. Chem. 271 (12): 6952–62. PMID 8636124.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bewarder N, Weinrich V, Budde P; et al. (1996). "In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation". Mol. Cell. Biol. 16 (9): 4735–43. PMID 8756631.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Saouaf SJ, Wolven A, Resh MD, Bolen JB (1997). "Palmitylation of Src family tyrosine kinases regulates functional interaction with a B cell substrate". Biochem. Biophys. Res. Commun. 234 (2): 325–9. doi:10.1006/bbrc.1997.6638. PMID 9177269.CS1 maint: Multiple names: authors list (link)
• Hegde R, Srinivasula SM, Ahmad M; et al. (1998). "Blk, a BH3-containing mouse protein that interacts with Bcl-2 and Bcl-xL, is a potent death agonist". J. Biol. Chem. 273 (14): 7783–6. PMID 9525867.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Oda H, Kumar S, Howley PM (1999). "Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9557–62. PMID 10449731.CS1 maint: Multiple names: authors list (link)
• Appel S, Filter M, Reis A; et al. (2002). "Physical and transcriptional map of the critical region for keratolytic winter erythema (KWE) on chromosome 8p22-p23 between D8S550 and D8S1759". Eur. J. Hum. Genet. 10 (1): 17–25. doi:10.1038/sj.ejhg.5200750. PMID 11896452.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lee S, Ha S, Chung M; et al. (2003). "Mouse DAM1 regulates pro-apoptotic activity of BLK in mammary epithelial cells". Cancer Lett. 188 (1–2): 121–6. PMID 12406557.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cho JY, Akbarali Y, Zerbini LF; et al. (2004). "Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene". J. Biol. Chem. 279 (19): 19512–22. doi:10.1074/jbc.M309074200. PMID 14970218.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)